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      SAK/PLK4 is required for centriole duplication and flagella development.

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          Abstract

          SAK/PLK4 is a distinct member of the polo-like kinase family. SAK-/- mice die during embryogenesis, whereas SAK+/- mice develop liver and lung tumors and SAK+/- MEFs show mitotic abnormalities. However, the mechanism underlying these phenotypes is still not known.

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          Author and article information

          Journal
          Curr Biol
          Current biology : CB
          Elsevier BV
          0960-9822
          0960-9822
          Dec 20 2005
          : 15
          : 24
          Affiliations
          [1 ] Cancer Research UK Cell Cycle Genetics Research Group, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom. mbcd2@cam.ac.uk
          Article
          S0960-9822(05)01451-X
          10.1016/j.cub.2005.11.042
          16326102
          e048c87d-5c79-4978-9b4f-5582ba7693a5
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