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      Mast cell-neural interactions contribute to pain and itch

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          Summary

          Mast cells are best recognized for their role in allergy and anaphylaxis, but increasing evidence supports their role in neurogenic inflammation leading to pain and itch. Mast cells act as a “ power house” by releasing algogenic and pruritogenic mediators, which initiate a reciprocal communication with specific nociceptors on sensory nerve fibers. Consequently, nerve fibers release inflammatory and vasoactive neuropeptides, which in turn activate mast cells in a feedback mechanism, thus promoting a vicious cycle of mast cell and nociceptor activation leading to neurogenic inflammation and pain/pruritus. Mechanisms underlying mast cell differentiation, activation, and inter-cellular interactions with inflammatory, vascular and neural systems are deeply influenced by their microenvironment, imparting enormous heterogeneity and complexity in understanding their contribution to pain and pruritus. Neurogenic inflammation is central to both pain and pruritus, but specific mediators released by mast cells to promote this process may vary depending upon their location, stimuli, underlying pathology, gender and species. Therefore, in this review we present the contribution of mast cells in pathological conditions, including distressing pruritus exacerbated by psychologic stress and experienced by the majority of patients with psoriasis and atopic dermatitis and in different pain syndromes due to mastocytosis, sickle cell disease and cancer.

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          Author and article information

          Journal
          7702118
          4161
          Immunol Rev
          Immunol. Rev.
          Immunological reviews
          0105-2896
          1600-065X
          28 November 2017
          March 2018
          01 March 2019
          : 282
          : 1
          : 168-187
          Affiliations
          [1 ]Vascular Biology Center, Division of Hematology/Oncology/Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA
          [2 ]Department of Dermatology, University of Eastern Finland and Kuopio University Hospital, P.O.B. 100, 70029 KYS, Kuopio, Finland
          Author notes
          [* ]Communicating Authors Address for Correspondence. Kalpna Gupta, Ph.D., Vascular Biology Center, Medicine - Hematology, Oncology and Transplantation, University of Minnesota, Mayo Mail Code 480; 420 Delaware Street SE, Minneapolis, MN, 55455, USA, Phone: (+ 1) 612-625-7648, Fax: (+ 1) 612-625-6919, gupta014@ 123456umn.edu , Ilkka T. Harvima, M.D., Ph.D., Phone: + 358-50-4413620, ilkka.harvima@ 123456uef.fi

          DR KALPNA GUPTA (Orcid ID : 0000-0001-9381-9979)

          Article
          PMC5812374 PMC5812374 5812374 nihpa923140
          10.1111/imr.12622
          5812374
          29431216
          Categories
          Article

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