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      Cholesterol homeostasis failure in the brain: implications for synaptic dysfunction and cognitive decline.

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          Abstract

          Cholesterol is one of the most important molecules in cell physiology because of its involvement in several biological processes: for instance, it determines both physical and biochemical properties of cell membranes and proteins. Disruption to cholesterol homeostasis leads to coronary heart disease, atherosclerosis and metabolic syndrome. Strong evidence suggests that cholesterol also has a crucial role in the brain as various neurological and neurodegenerative disorders, including Alzheimer's, Huntington's and Parkinson diseases are associated with disruptions to cholesterol homeostasis. Here, we summarize the current knowledge about the role cholesterol plays at synaptic junctions and the pathological consequences caused by disruptions in the homeostatic maintenance of this compound.

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          Author and article information

          Journal
          Curr. Med. Chem.
          Current medicinal chemistry
          1875-533X
          0929-8673
          2014
          : 21
          : 24
          Affiliations
          [1 ] Department of Science, University Roma Tre, Viale G. Marconi, 446, I-00146 Roma, Italy. marco.segatto@uniroma3.it.
          Article
          CMC-EPUB-59433
          10.2174/0929867321666140303142902
          24606521
          e06e45b3-2078-4981-80a6-ad0b8d7c9f46
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