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      Effect of Free Fatty Acid on Myocardial Function During Hypoxia

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          Abstract

          The influence of exogenous free fatty acid (FFA) on hypoxic myocardial function was studied in isolated, isometric rat papillary muscles. In 95 % O<sub>2</sub>, no difference in developed tension was noted between muscles in glucose (5 mM) or FFA (oleic acid 1,800 µM ) buffer. During hypoxia (20 % O<sub>2</sub>), muscles in FFA or no substrate buffer developed less tension and in subsequent reoxygenation, recovered less function than muscles in glucose buffer (with or without added FFA). Prior stabilization in glucose eliminated these differences for muscles supplied with FFA or no substrate during hypoxia, although recovered function for muscles with no substrate remained deficient. Muscle thickness correlated inversely with control developed tension (g/mm<sup>2</sup>), but did not correlate with percent depression during hypoxia. This study failed to demonstrate a depressant effect of exogenous FFA on the mechanical performance of rat myocardium during hypoxia.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1972
          1972
          29 October 2008
          : 57
          : 6
          : 322-332
          Affiliations
          Cardiovascular Research Section, Rhode Island Hospital and Division of Biological and Medical Sciences, Brown University, Providence, R.I.
          Article
          169531 Cardiology 1972;57:322–332
          10.1159/000169531
          4668964
          © 1972 S. Karger AG, Basel

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          Page count
          Pages: 11
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