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Lipotoxicity: when tissues overeat :
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Abstract
<p class="first" id="d1275396e51">This review will provide the reader with an update
on our understanding of the adverse
effects of fatty acid accumulation in non-adipose tissues, a phenomenon known as lipotoxicity.
Recent studies will be reviewed. Cellular mechanisms involved in the lipotoxic response
will be discussed. Physiologic responses to lipid overload and therapeutic approaches
to decreasing lipid accumulation will be discussed, as they add to our understanding
of important pathophysiologic mechanisms.
</p>