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      Possible Role of Prolactin and Pineal Prolactin-Regulating Substances in Pineal-Mediated Gonadal Atrophy in Hamsters


      Hormone Research in Paediatrics

      S. Karger AG

      Homografts, Hamster, Pineal, Prolactin, Blinding, Photoperiod, Pituitary

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          Homoplastic anterior pituitaries were transplanted beneath the renal capsule of adult male, Syrian golden hamsters and the effects studied on the gonadal and accessory organ atrophy following bilateral optic enucleation or placement in reduced (L/D = 10/14 h) photoperiods. In all cases, control hamsters, bearing kidney fragments transplanted beneath their renal capsules, showed gonadal atrophy and reduced blood levels of prolactin and LH at 8–10 weeks following light deprivation. On the other hand, hamsters, bearing three or four homoplastic pituitary grafts, showed complete maintenance of gonadal and accessory weights as well as normal or supranormal serum prolactin levels. Prolactin, but not LH, levels were maintained in hypophysectomized male hamsters bearing pituitary homografts. These results point out the significant role played by prolactin, and possibly that of pineal prolactin-regulating factors, in pineal-mediated gonadal atrophy.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 12
          : 3
          : 137-148
          Department of Anatomy, University of Arizona, Tucson, Ariz.
          179115 Horm Res 1980;12:137–148
          © 1980 S. Karger AG, Basel

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          Pages: 12
          Original Paper


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