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      Mechanisms of blue light-induced eye hazard and protective measures: a review

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      Biomedicine & Pharmacotherapy
      Elsevier BV

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          Abstract

          <p class="first" id="d14440263e107">The risk of blue light exposure to human health has attracted increased research attention. Blue light, with relatively high energy, can cause irreversible photochemical damage to eye tissue. Excessive exposure of the eye to blue light tends to cause a series of alterations, such as oxidative stress, mitochondrial apoptosis, inflammatory apoptosis, mitochondrial apoptosis and DNA damage, resulting in the development of dry eye disease, glaucoma, and keratitis. Accordingly, physical protection, chemical and pharmaceutical protective measures, gene therapy, and other methods are widely used in the clinical treatment of blue light hazard. We reviewed the studies on possible blue light-induced signaling pathways and mechanisms in the eye and summarized the therapeutic approaches to addressing blue light hazard. </p>

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          Author and article information

          Journal
          Biomedicine & Pharmacotherapy
          Biomedicine & Pharmacotherapy
          Elsevier BV
          07533322
          October 2020
          October 2020
          : 130
          : 110577
          Article
          10.1016/j.biopha.2020.110577
          32763817
          e0a17edb-11ef-4dea-9588-569d6b554ea0
          © 2020

          https://www.elsevier.com/tdm/userlicense/1.0/

          http://creativecommons.org/licenses/by-nc-nd/4.0/

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