11
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways

      1 , 2 , 3 , 4 , 5
      Immunology
      Wiley

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Chloroquines are 4-aminoquinoline-based drugs mainly used to treat malaria. At pharmacological concentrations, they have significant effects on tissue homeostasis, targeting diverse signaling pathways in mammalian cells. A key target pathway is autophagy, which regulates macromolecule turnover in the cell. In addition to affecting cellular metabolism and bioenergetic flow equilibrium, autophagy plays a pivotal role at the interface between inflammation and cancer progression. Chloroquines consequently have critical effects in tissue metabolic activity and importantly, in key functions of the immune system. In this article, we will review the work addressing the role of chloroquines in the homeostasis of mammalian tissue, and the potential strengths and weaknesses concerning their use in cancer therapy.

          Related collections

          Author and article information

          Journal
          Immunology
          Immunology
          Wiley
          0019-2805
          1365-2567
          December 03 2019
          March 2020
          December 22 2019
          March 2020
          : 159
          : 3
          : 257-278
          Affiliations
          [1 ]Union of Education and Science Workers (EGITIM SEN), Diyarbakir Branch Diyarbakir Turkey
          [2 ]Department of Molecular Biology and Genetics Science Faculty Dicle University Diyarbakir Turkey
          [3 ]Microbiology‐Immunology Northwestern University Feinberg School of Medicine Chicago IL USA
          [4 ]Department of Natural Sciences Joliet Jr College Joliet IL USA
          [5 ]First Department of Pediatrics National and Kapodistrian University of Athens Athens Greece
          Article
          10.1111/imm.13160
          7011648
          31782148
          e0a1f110-90b4-46d9-a95f-59be6c73a41a
          © 2020

          http://onlinelibrary.wiley.com/termsAndConditions#vor

          http://doi.wiley.com/10.1002/tdm_license_1.1

          History

          Comments

          Comment on this article