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      Genomic Characterizations of Clade III Lineage of Candida auris, California, USA

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          Abstract

          Candida auris is an emerging multidrug-resistant yeast. We describe an ongoing C. auris outbreak that began in October 2019 in Los Angeles, California, USA. We used genomic analysis to determine that isolates from 5 of 6 patients belonged to clade III; 4 isolates were closely related.

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          Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses.

          Candida auris, a multidrug-resistant yeast that causes invasive infections, was first described in 2009 in Japan and has since been reported from several countries.
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            Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital.

            A single strain of a novel ascomycetous yeast species belonging to the genus Candida was isolated from the external ear canal of an inpatient in a Japanese hospital. Analyses of the 26S rDNA D1/D2 domain, nuclear ribosomal DNA ITS region sequences, and chemotaxonomic studies indicated that this strain represents a new species with a close phylogenetic relationship to Candida ruelliae and Candida haemulonii in the Metschnikowiaceae clade. This strain grew well at 40 degrees C, but showed slow and weak growth at 42 degrees C. The taxonomic description of Candida auris sp. nov. is proposed (type strain JCM15448T= CBS10913T= DSM21092T).
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              A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009-17) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance.

              Candida auris has emerged globally as an MDR nosocomial pathogen in ICU patients.
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                Author and article information

                Journal
                Emerg Infect Dis
                Emerg Infect Dis
                EID
                Emerging Infectious Diseases
                Centers for Disease Control and Prevention
                1080-6040
                1080-6059
                April 2021
                : 27
                : 4
                : 1223-1227
                Affiliations
                [1]University of California, Los Angeles, California, USA
                Author notes
                Address for correspondence : Shangxin Yang, UCLA Clinical Microbiology Laboratory, 11633 San Vicente Blvd, Los Angeles, CA 90049, USA; email: shangxinyang@ 123456mednet.ucla.edu
                Article
                20-4361
                10.3201/eid2704.204361
                8007294
                33755003
                e0a91300-fd07-47cc-9d03-ab9f78cede6a
                History
                Categories
                Dispatch
                Dispatch
                Characterizations of Clade III Lineage of Candida auris, California, USA

                Infectious disease & Microbiology
                yeast,fungal infections,candida auris,los angeles,california,clade iii,outbreak,genomic characterization,united states,fungi,antimicrobial resistance,candida

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