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      The Short-Term Effect of Adding Brimonidine 0.2% to Timolol Treatment in Patients with Open-Angle Glaucoma


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          Brimonidine, a highly selective α<sub>2</sub>-adrenoceptor agonist, was studied to determine its ocular hypotensive effect and side effects in patients with elevated intraocular pressure (IOP) while on continuing therapy with timolol. This was a prospective, randomized, placebo-controlled study in 15 patients with primary open-angle or pseudoexfoliation glaucoma on therapy receiving timolol 0.5% twice daily, with IOP greater than or equal to 22 mm Hg in one eye. IOP measurements, blood pressure and pulse rate were assessed on 2 days at a baseline and 1, 2, 4, 6 and 8 h later. A single drop of brimonidine 0.2% or placebo was added to treatment with timolol. The reductions in IOP at all time intervals observed with brimonidine + timolol were significantly greater than those with timolol + placebo. The maximum mean net decrease in IOP was 19.23 ± 10.60% at 4 h. Statistically significant decreases in systemic blood pressure and pulse rate without clinical symptoms were observed in the group receiving brimonidine + timolol. This study suggests that a combination of brimonidine and timolol may have potential in the treatment of glaucoma. Further clinical trials with brimonidine are indicated to assess its further role as adjunctive agent.

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          Author and article information

          S. Karger AG
          August 1999
          09 July 1999
          : 213
          : 4
          : 228-233
          Department of Ophthalmology, School of Medicine, Kocaeli University, Kocaeli, Turkey
          27427 Ophthalmologica 1999;213:228–233
          © 1999 S. Karger AG, Basel

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          Page count
          Figures: 2, Tables: 4, References: 25, Pages: 6
          Original Paper · Travail original · Originalarbeit

          Vision sciences,Ophthalmology & Optometry,Pathology
          Additivity,Intraocular pressure,Brimonidine,Glaucoma,Timolol


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