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      Kluyveromyces lactis killer toxin inhibits adenylate cyclase of sensitive yeast cells

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      Nature
      Springer Nature

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          Studies on the nature of the killer factor produced by Saccharomyces cerevisiae.

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            Isolation and characterization of yeast mutants deficient in adenylate cyclase and cAMP-dependent protein kinase.

            Mutants of Saccharomyces cerevisiae that require cAMP for growth have been isolated. Some of the mutants isolated were deficient in adenylate cyclase activity and mapped at a locus, cyr1, located near the centromere of chromosome X. Growth of cells carrying the cyr1 mutation was arrested at the G1 phase of the yeast cell cycle in the absence of cAMP. The cyr1 mutation was suppressed by a secondary mutation designated bcy1. The bcy1 mutation bypassed the need for cAMP for growth. The bcy1 mutants had extremely low levels of cAMP-binding protein and cAMP-dependent protein kinase but produced a high level of cAMP-independent protein kinase. The results indicate that cAMP is an essential factor for yeast cells to proceed through the cell cycle via the activation of protein kinase.
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              Curing of a killer factor in Saccharomyces cerevisiae.

              Many standard laboratory stocks of yeast are able to kill other yeast strains. This property has not been generally recognized because killing is observed only at low pH and not at the pH of standard media. In all strains examined, the genetic determinant for the killer trait shows non-Mendelian inheritance. The segregation patterns of our killer strains indicate that this killer determinant may be different from the killer previously described. Treatment of a killer strain with cycloheximide, but not with ethidium bromide, converts it into a sensitive nonkiller.
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                Author and article information

                Journal
                Nature
                Nature
                Springer Nature
                0028-0836
                1476-4687
                August 1983
                August 1983
                : 304
                : 5925
                : 464-466
                Article
                10.1038/304464a0
                e0b0955b-0c6a-4e35-b97a-a0f4961e389e
                © 1983

                http://www.springer.com/tdm

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