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      Selective disappearance of great tits with short telomeres in urban areas

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      Proceedings of the Royal Society B: Biological Sciences

      The Royal Society

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          Urbanization, Biodiversity, and Conservation

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            Oxidative stress shortens telomeres.

            Telomeres in most human cells shorten with each round of DNA replication, because they lack the enzyme telomerase. This is not, however, the only determinant of the rate of loss of telomeric DNA. Oxidative damage is repaired less well in telomeric DNA than elsewhere in the chromosome, and oxidative stress accelerates telomere loss, whereas antioxidants decelerate it. I suggest here that oxidative stress is an important modulator of telomere loss and that telomere-driven replicative senescence is primarily a stress response. This might have evolved to block the growth of cells that have been exposed to a high risk of mutation.
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              Compensation for a bad start grow now pay later

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                Author and article information

                Journal
                Proceedings of the Royal Society B: Biological Sciences
                Proc. R. Soc. B
                The Royal Society
                0962-8452
                1471-2954
                September 06 2017
                September 06 2017
                : 284
                : 1862
                : 20171349
                Article
                10.1098/rspb.2017.1349
                © 2017

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