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HPV DNA genotyping and methylation of gene p16INK4A in cervical LSIL
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Abstract
DNA methylation is the most important epigenetic change involved in the control of
gene expression in human cells. Methylation of the p16(INK4a) gene occurs early in
the development of cervical cancer. Low-grade squamous intraepithelial lesions (LSILs)
are prevalent, and their behavior is variable.