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A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia :
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Abstract
<p class="first" id="d1134092e77">A method to measure cutaneous hyperalgesia to thermal
stimulation in unrestrained
animals is described. The testing paradigm uses an automated detection of the behavioral
end-point; repeated testing does not contribute to the development of the observed
hyperalgesia. Carrageenan-induced inflammation resulted in significantly shorter paw
withdrawal latencies as compared to saline-treated paws and these latency changes
corresponded to a decreased thermal nociceptive threshold. Both the thermal method
and the Randall-Selitto mechanical method detected dose-related hyperalgesia and its
blockade by either morphine or indomethacin. However, the thermal method showed greater
bioassay sensitivity and allowed for the measurement of other behavioral parameters
in addition to the nociceptive threshold.
</p>