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      A prenylflavone, artonin E, as arachidonate 5-lipoxygenase inhibitor

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          Abstract

          Several naturally occurring prenylflavones were tested for their inhibitory actions on arachidonate 5-lipoxygenase purified from porcine leukocytes. Of the compounds tested, artonin E (5'-hydroxymorusin) exhibited the most potent inhibition on arachidonate 5-lipoxygenase (IC50 = 0.36 microM). Arachidonate 12-lipoxygenase purified from porcine leukocytes and human platelets, 15-lipoxygenase from rabbit reticulocytes and fatty acid cyclooxygenase from bovine vesicular glands were inhibited by the compound only at higher concentrations (IC50 = 2.3, 11, 5.2 and 2.5 microM, respectively).

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          Author and article information

          Journal
          Biochemical Pharmacology
          Biochemical Pharmacology
          Elsevier BV
          00062952
          January 1991
          January 1991
          : 41
          : 1
          : 115-118
          Article
          10.1016/0006-2952(91)90018-Z
          1986735
          e103e7ba-f3fb-4a39-a841-74e14d5a73df
          © 1991

          https://www.elsevier.com/tdm/userlicense/1.0/

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