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      DTASelect and Contrast: tools for assembling and comparing protein identifications from shotgun proteomics.

      1 , ,
      Journal of proteome research
      American Chemical Society (ACS)

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          Abstract

          The components of complex peptide mixtures can be separated by liquid chromatography, fragmented by tandem mass spectrometry, and identified by the SEQUEST algorithm. Inferring a mixture's source proteins requires that the identified peptides be reassociated. This process becomes more challenging as the number of peptides increases. DTASelect, a new software package, assembles SEQUEST identifications and highlights the most significant matches. The accompanying Contrast tool compares DTASelect results from multiple experiments. The two programs improve the speed and precision of proteomic data analysis.

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          Author and article information

          Journal
          J Proteome Res
          Journal of proteome research
          American Chemical Society (ACS)
          1535-3893
          1535-3893
          March 20 2003
          : 1
          : 1
          Affiliations
          [1 ] Department of Molecular Biotechnology, University of Washington, Seattle, Washington 98195, USA. dtabb@u.washington.edu
          Article
          NIHMS168865
          10.1021/pr015504q
          2811961
          12643522
          e11b1317-1a8f-4dd5-975b-76df7af2c867
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