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      • Record: found
      • Abstract: found
      • Article: found

      Degenerative Changes in Maculas of Rhesus Monkeys

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          Abstract

          In the hope of identifying an animal model for age-related macular degeneration (AMD) we undertook a pilot investigation of aged rhesus monkeys. Twenty-nine monkeys from a seminatural colony were examined at the Caribbean Primate Research Center. Macular drusen were found in 74% of the monkey eyes. Alterations of the retinal pigment epithelium within the macula were noted in 45% of the eyes. Fluorescein angiography in selected animals revealed window defects consistent with drusen. None of this sample showed the exudative form of AMD or disciform scarring. One typical monkey underwent special studies including measurement of visual resolution by electrophysiological study of the retinal and visual cortex. Application of human criteria to this animal supported the diagnosis of early AMD. Histopathologic study of one eye by transmission electron microscopy confirmed the presence of drusen with nearly identical ultrastructural features to those found in the human pigment epithelium in AMD.

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          Author and article information

          Journal
          Journal ID (publisher-id): OPH
          Journal ID (nlm-ta): Ophthalmologica
          Journal ID (doi): 10.1159/issn.0030-3755
          Title: Ophthalmologica
          Publisher: S. Karger AG
          ISSN (Print): 0030-3755
          ISSN (Electronic): 1423-0267
          Publication date Subscription-year: 1988
          Publication date (Print): 1988
          Publication date (Electronic): 31 March 2010
          Volume: 196
          Issue: 3
          Pages: 143-150
          Affiliations
          Departments of aOphthalmology and bPhysiology, College of Medicine, University of Florida, Gainesville, Fla., USA; cCaribbean Primate Research Center, University of Puerto Rico, Sabana Seca, P.R.
          Article
          Publisher ID: 309891 Other ID: Ophthalmologica 1988;196:143–150
          DOI: 10.1159/000309891
          PubMed ID: 3405585
          SO-VID: e1806cce-9d6c-413e-ba5c-feb47b3d8900
          Copyright © © 1988 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 21 September 1987
          Date accepted : 09 October 1987
          Page count
          Pages: 8
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
          Keywords: Macaca mulatta,Drusen,Tuning,Acuity,Rhesus monkey,Primate,Retina,Macular Degeneration,Aging macula
          Data availability:
          ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
          Keywords: Macaca mulatta, Drusen, Tuning, Acuity, Rhesus monkey, Primate, Retina, Macular Degeneration, Aging macula

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