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      The Discovery of Renal Contrast Media in Berlin

      a , b

      American Journal of Nephrology

      S. Karger AG

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          After X-rays were detected and cystoscopes had become available, progress in nephrology depended on the development of contrast media which would permit imaging of the kidneys and the urinary system. We describe how A. Binz and C. Räth, two chemists at the Agricultural Academy in Berlin, synthesized iodinated derivatives which were potent chemotherapeutics. Moses Swick tested the substances in the clinics of L. Lichtwitz (Hamburg) and A. von Lichtenberg (Berlin) and discovered a rapid renal excretion. He also observed that an iodinated N-acetylated derivative, later named Uro-Selectan, amplified X-ray contrast after intravenous application. With this substance and other derivatives which were produced by Schering-Kahlbaum AG, the door was open for excretion urography.

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          Author and article information

          Am J Nephrol
          American Journal of Nephrology
          S. Karger AG
          July 2002
          27 June 2002
          : 22
          : 2-3
          : 295-299
          aDepartment of Clinical Physiology, Freie Universität Berlin, and bDepartment of Diagnostic and Interventional Radiology, Klinikum Ernst-von-Bergmann, Potsdam, Germany
          63777 Am J Nephrol 2002;22:295–299
          © 2002 S. Karger AG, Basel

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          Page count
          Figures: 8, Tables: 2, References: 18, Pages: 5
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/63777
          Diagnostics of Kidney Diseases

          Cardiovascular Medicine, Nephrology


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