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      Metabolism of praziquantel in kingfish Seriola lalandi.

      1 , ,
      Diseases of aquatic organisms
      Inter-Research Science Center

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          Abstract

          Investigations into the metabolism of drugs used in aquatic animal therapy are useful for understanding the mechanisms of xenobiotic transformation systems and can aid the development of dosing regimens. This study investigated the metabolism of the synthetic anthelmintic praziquantel, which has application in helminthiasis treatment for several fish species including kingfish Seriola lalandi, a commercial aquaculture finfish species. At least 7 mono- or dihydroxylated derivatives of the parent compound were identified in kingfish after administration of a 150 mg kg(-1) oral praziquantel dose, paralleling findings in mammals. The structure of one representative mono-hydroxylated species that was prominent in the skin, muscle, liver, kidney and plasma of kingfish was investigated using fragmentation experiments; this revealed that hydroxylation of the parent molecule occurred in the tetrahydroisoquinoline region of praziquantel, analogous with mammalian metabolites, but different to that of the active mammalian metabolite (trans-4-OH-praziquantel). The implications of these findings with regard to biotransformation systems for this drug in mammals and fish are discussed.

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          Author and article information

          Journal
          Dis. Aquat. Org.
          Diseases of aquatic organisms
          Inter-Research Science Center
          0177-5103
          0177-5103
          Jan 24 2008
          : 78
          : 3
          Affiliations
          [1 ] National Institute of Water and Atmospheric Research, PO Box 109 695, Auckland, New Zealand. l.tubbs@niwa.co.nz
          Article
          10.3354/dao01873
          18380221
          e18a231c-728f-4a95-a64e-bb67f1745434
          History

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