Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
18
March
2016
Publication date Collection: 2016
Volume: 11
Issue: 3
Electronic Location Identifier: e0150569
Affiliations
[1
]Centre de Recherche sur l’Inflammation (CRI), UMR 1149 Inserm, Université Paris Diderot,
Service d’Hépatologie, AP-HP Hôpital Beaujon, Paris, France
[2
]Department of Gastroenterology, St Vincent’s Hospital, University of Melbourne, Melbourne,
VIC, Australia
[3
]Department of Infectious Diseases and Hepatology, Medical University of Białystok,
15–540, Białystok, Poland
[4
]UCM Digestive Diseases and CIBERehd, Valme University Hospital, University of Seville,
Seville, Spain
[5
]Biostatistics, PROMETRIS GmbH, 68219, Mannheim, Germany
[6
]Global Product Development Medical Affairs, F. Hoffmann-La Roche Ltd, 4074, Basel,
Switzerland
[7
]Liver Institute of Virginia, Bon Secours Health System, Richmond and Newport News,
Richmond, VA, United States of America
National Taiwan University Hospital, TAIWAN
Author notes
Competing Interests: These studies were funded by F. Hoffmann-La Roche Ltd. T Asselah: speaker/consultant:
Roche, Boehringer-Ingelheim, AbbVie, Achillion, Bristol-Myers Squibb, Gilead Sciences,
Janssen, Merck. AJ Thompson: support by an NHMRC fellowship (1053344); consultant
to Abbvie, Bristol-Myers Squibb, Gilead Sciences, Merck, Roche Diagnostics, Spring
Bank Pharmaceuticals, Arrowhead; research support from Abbvie, Gilead Sciences, Merck;
speaker for Abbvie, Bristol-Myers Squibb, Gilead Sciences and Merck. R Flisiak: a
speaker and advisor to AbbVie, Bristol-Myers Squibb, Gilead, Janssen, Merck, Novartis,
Roche. M Romero-Gomez: consulting fees from AbbVie, Bristol-Myers Squibb, Gilead,
Janssen, Merck, Roche Farma, Ferrer, Boeringher Ingelgheim and Novartis; grant support
from Roche, Merck and Gilead; and speaker fees from AbbVie, Gilead, Janssen, Merck,
Roche Farma, Boeringher Ingelgheim, GSK. Diethelm Messinger is employed by PROMETRIS
GmbH. PROMETRIS GmbH has a contract with F. Hoffmann La-Roche Ltd to provide statistical
support. G Bakalos is employed by F. Hoffmann-La Roche Ltd. ML Shiffman: consulting
fees from AbbVie, Achillion, Bristol-Myers Squibb, Gilead, Janssen, Merck, Roche/Genentech
and Vertex; grant support from AbbVie, Achillion, Beckman-Colter, Bristol-Myers Squibb,
Boehringer Ingelheim, Conatus, Gilead, Hologic, Intercept, Lumena and Novartis; and
speaker fees from AbbVie, Bayer, Gilead, Janssen, Merck, Roche/Genentech and Vertex.
Peginterferon alfa-2a (PEGASYS®) and ribavirin (COPEGUS®) are both products marketed
by F. Hoffmann-La Roche, Basel, Switzerland and protected by various intellectual
property rights. There are no other patents, products in development or marketed products
to declare. This does not alter the authors' adherence to all the PLOS ONE policies
on sharing data and materials, as detailed online in the guide for authors.
Conceived and designed the experiments: TA MRG DM GB. Performed the experiments: RF
DM. Analyzed the data: TA RF DM GB. Wrote the paper: TA AJT RF MRG DM GB MLS.
Article
Publisher ID:
PONE-D-15-40146
DOI: 10.1371/journal.pone.0150569
PMC ID: 4798721
PubMed ID: 26991780
SO-VID: e18b8177-2226-466f-a908-babc9d041faa
Copyright © © 2016 Asselah et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
These studies were funded by F. Hoffmann-La Roche Ltd. F. Hoffmann-La Roche participated
in the design and conduct of the study, in the analysis and interpretation of the
data, and in the preparation and review of the manuscript before submission. Third-party
medical writing assistance, provided by Blair Jarvis MSc, ELS, of Health Interactions,
but not editorial content development sufficient to meet International Committee of
Medical Journal Editors (ICMJE) authorship criteria, was provided by Health Interactions
and funded by F. Hoffmann-La Roche Ltd. F. Hoffmann-La Roche Ltd provided support
in the form of salaries for authors [GB]. PROMETRIS GmbH is the clinical research
organization contracted by F. Hoffmann-La Roche Ltd to provide data management and
statistical services. PROMETRIS GmbH provided support in the form of salaries for
authors [DM], participated in the design and conduct of the study, in the analysis
and interpretation of the data, and in the preparation and review of the manuscript
before submission. The specific roles of these authors are articulated in the ‘author
contributions’ section.
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Gastroenterology and Hepatology
Subject:
Liver Diseases
Subject:
Cirrhosis
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Flaviviruses
Subject:
Hepacivirus
Subject:
Hepatitis C virus
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Flaviviruses
Subject:
Hepacivirus
Subject:
Hepatitis C virus
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Flaviviruses
Subject:
Hepacivirus
Subject:
Hepatitis C virus
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Flaviviruses
Subject:
Hepacivirus
Subject:
Hepatitis C virus
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Hepatitis viruses
Subject:
Hepatitis C virus
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Hepatitis viruses
Subject:
Hepatitis C virus
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Hepatitis viruses
Subject:
Hepatitis C virus
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Platelets
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Platelets
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Platelets
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Platelets
Subject:
Medicine and Health Sciences
Subject:
Hematology
Subject:
Blood
Subject:
Platelets
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
Platelets
Subject:
Biology and Life Sciences
Subject:
Developmental Biology
Subject:
Fibrosis
Subject:
Research and Analysis Methods
Subject:
Mathematical and Statistical Techniques
Subject:
Statistical Methods
Subject:
Regression Analysis
Subject:
Physical Sciences
Subject:
Mathematics
Subject:
Statistics (Mathematics)
Subject:
Statistical Methods
Subject:
Regression Analysis
Subject:
Medicine and Health Sciences
Subject:
Pharmaceutics
Subject:
Dose Prediction Methods
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Compounds
Subject:
Organic Compounds
Subject:
Amino Acids
Subject:
Aliphatic Amino Acids
Subject:
Alanine
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Organic Chemistry
Subject:
Organic Compounds
Subject:
Amino Acids
Subject:
Aliphatic Amino Acids
Subject:
Alanine
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Amino Acids
Subject:
Aliphatic Amino Acids
Subject:
Alanine
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Enzymology
Subject:
Enzymes
Subject:
Transferases
Subject:
Aminotransferases
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Enzymes
Subject:
Transferases
Subject:
Aminotransferases
