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Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride.

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      Abstract

      Histamine is a biogenic amine with fundamental roles in circulatory and immune systems. We report a fluorescent small molecule (Histamine Blue) for imaging intracellular histamine in live basophils and macrophages. Histamine Blue is a fluorescent mesoionic acid fluoride that turns on upon reaction with histamine. The selective response of Histamine Blue enabled the visualization of intracellular histamine under different physiological conditions.

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      Affiliations
      [1 ] Institute for Biomedical Research, Barcelona Science Park, Spain.
      Journal
      Chem. Commun. (Camb.)
      Chemical communications (Cambridge, England)
      Royal Society of Chemistry (RSC)
      1364-548X
      1359-7345
      Jul 28 2012
      : 48
      : 59
      22715465
      10.1039/c2cc32292g

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