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      Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride.

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          Abstract

          Histamine is a biogenic amine with fundamental roles in circulatory and immune systems. We report a fluorescent small molecule (Histamine Blue) for imaging intracellular histamine in live basophils and macrophages. Histamine Blue is a fluorescent mesoionic acid fluoride that turns on upon reaction with histamine. The selective response of Histamine Blue enabled the visualization of intracellular histamine under different physiological conditions.

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          Author and article information

          Affiliations
          [1 ] Institute for Biomedical Research, Barcelona Science Park, Spain.
          Journal
          Chem. Commun. (Camb.)
          Chemical communications (Cambridge, England)
          Royal Society of Chemistry (RSC)
          1364-548X
          1359-7345
          Jul 28 2012
          : 48
          : 59
          10.1039/c2cc32292g
          22715465

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