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Risk of serious infection in biological treatment of patients with rheumatoid arthritis: a systematic review and meta-analysis
Jasvinder A Singh ,
Chris Cameron ,
Shahrzad Noorbaloochi ,
Tyler Cullis ,
Matthew Tucker ,
Robin Christensen ,
Elizabeth Tanjong Ghogomu ,
Doug Coyle ,
Tammy Clifford ,
Peter Tugwell ,
George A Wells
July 2015
July 2015
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Abstract
Serious infections are a major concern for patients considering treatments for rheumatoid
arthritis. Evidence is inconsistent as to whether biological drugs are associated
with an increased risk of serious infection compared with traditional disease-modifying
antirheumatic drugs (DMARDs). We did a systematic review and meta-analysis of serious
infections in patients treated with biological drugs compared with those treated with
traditional DMARDs.