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      Exploring Autophagy in Drosophila

      review-article
      Author(s): 1 , 2 , 1 , 3 , *
      Publication date (Electronic):
      Journal: Cells
      Publisher: MDPI
      Keywords: Atg8a, autophagy, Drosophila, Ref(2)P/p62

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          Abstract

          Autophagy is a catabolic process in eukaryotic cells promoting bulk or selective degradation of cellular components within lysosomes. In recent decades, several model systems were utilized to dissect the molecular machinery of autophagy and to identify the impact of this cellular “self-eating” process on various physiological and pathological processes. Here we briefly discuss the advantages and limitations of using the fruit fly Drosophila melanogaster, a popular model in cell and developmental biology, to apprehend the main pathway of autophagy in a complete animal.

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          The role of Atg proteins in autophagosome formation.

          Noboru Mizushima, Tamotsu Yoshimori, Yoshinori Ohsumi (2011)
          Macroautophagy is mediated by a unique organelle, the autophagosome, which encloses a portion of cytoplasm for delivery to the lysosome. Autophagosome formation is dynamically regulated by starvation and other stresses and involves complicated membrane reorganization. Since the discovery of yeast Atg-related proteins, autophagosome formation has been dissected at the molecular level. In this review we describe the molecular mechanism of autophagosome formation with particular focus on the function of Atg proteins and the long-standing discussion regarding the origin of the autophagosome membrane.
          Article 0 comments Cited 1120 times – based on 0 reviews     Review now
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            Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease

            Scott Gratz, Alexander M. Cummings, Jennifer Nguyen … (2013)
            We have adapted a bacterial CRISPR RNA/Cas9 system to precisely engineer the Drosophila genome and report that Cas9-mediated genomic modifications are efficiently transmitted through the germline. This RNA-guided Cas9 system can be rapidly programmed to generate targeted alleles for probing gene function in Drosophila.
            Article 0 comments Cited 414 times – based on 0 reviews     Review now
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              A unified nomenclature for yeast autophagy-related genes.

              Daniel Klionsky, James M. Cregg, William A Dunn … (2003)
              Article 0 comments Cited 291 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Cells
                Journal ID (iso-abbrev): Cells
                Journal ID (publisher-id): cells
                Title: Cells
                Publisher: MDPI
                ISSN (Electronic): 2073-4409
                Publication date (Electronic): 12 July 2017
                Publication date Collection: September 2017
                Volume: 6
                Issue: 3
                Electronic Location Identifier: 22
                Affiliations
                [1 ]Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, H-1117 Budapest, Hungary; concrete05@ 123456gmail.com
                [2 ]Catalan Institute of Oncology-IDIBELL, Laboratory of Cancer Metabolism (LMC), Hospital Duran i Reynals, 08908 Barcelona, Spain; caroline.mauvezin@ 123456gmail.com
                [3 ]Institute of Genetics, Biological Research Centre, Hungarian Academy of Sciences, H-6726 Szeged, Hungary
                Author notes
                [* ]Correspondence: szmrt@ 123456elte.hu ; Tel.: +36-62-599-793
                Author information
                https://orcid.org/0000-0001-7374-667X
                https://orcid.org/0000-0003-4220-7272
                Article
                Publisher ID: cells-06-00022
                DOI: 10.3390/cells6030022
                PMC ID: 5617968
                PubMed ID: 28704946
                SO-VID: e1a6d7f3-c471-414e-8ed5-48914ccf4e1b
                Copyright © © 2017 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 17 June 2017
                Date accepted : 08 July 2017
                Categories
                Subject: Review

                Keywords: atg8a,autophagy,drosophila,ref(2)p/p62
                Data availability:
                Keywords: atg8a, autophagy, drosophila, ref(2)p/p62

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