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The QT Interval in Patients with SARS-CoV-2 Infection Treated with Hydroxychloroquine/Azithromycin
Preprint
Ehud Chorin ,
Matthew Dai ,
Eric Shulman ,
Lailt Wadhwani ,
Roi Bar Cohen ,
Chirag Barbhaiya ,
Anthony Aizer ,
Douglas Holmes ,
Scott Bernstein ,
Michael Soinelli ,
David S Park ,
Larry Chinitz ,
Lior Jankelosn
April 03 2020
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Abstract
We report the change in the QT interval in 84 adult patients with SARS-CoV-2 infection treated with Hydroxychloroquine/Azithromycin combination. QTc prolonged maximally from baseline between days 3 and 4. in 30% of patients QTc increased by greater than 40ms. In 11% of patients QTc increased to >500 ms, representing high risk group for arrhythmia. The development of acute renal failure but not baseline QTc was a strong predictor of extreme QTc prolongation.