Blog
About

  • Record: found
  • Abstract: found
  • Article: not found

Central nervous system pericytes in health and disease.

Nature neuroscience

Signal Transduction, Models, Biological, Blood-Brain Barrier, physiology, Central Nervous System Diseases, pathology, Humans, Neovascularization, Pathologic, Neovascularization, Physiologic, Pericytes, Receptors, Notch

Read this article at

ScienceOpenPublisherPMC
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Abstract

      Pericytes are uniquely positioned within the neurovascular unit to serve as vital integrators, coordinators and effectors of many neurovascular functions, including angiogenesis, blood-brain barrier (BBB) formation and maintenance, vascular stability and angioarchitecture, regulation of capillary blood flow and clearance of toxic cellular byproducts necessary for proper CNS homeostasis and neuronal function. New studies have revealed that pericyte deficiency in the CNS leads to BBB breakdown and brain hypoperfusion resulting in secondary neurodegenerative changes. Here we review recent progress in understanding the biology of CNS pericytes and their role in health and disease.

      Related collections

      Author and article information

      Journal
      22030551
      4020628
      10.1038/nn.2946

      Comments

      Comment on this article