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      Transcriptional regulation by the phosphorylation-dependent factor CREB.

      Nature reviews. Molecular cell biology

      Transcription, Genetic, physiology, Transcription Factors, Trans-Activators, metabolism, genetics, Stress, Physiological, Second Messenger Systems, Repressor Proteins, Regulatory Sequences, Nucleic Acid, Protein Processing, Post-Translational, Protein Conformation, Phosphorylation, Nuclear Proteins, Multigene Family, Models, Molecular, Models, Genetic, Mice, Transgenic, Mice, Knockout, Mice, Macromolecular Substances, Leucine Zippers, Human T-lymphotropic virus 1, Growth Substances, Gene Products, tax, Gene Expression Regulation, DNA-Binding Proteins, DNA Methylation, Cyclic AMP-Dependent Protein Kinases, chemistry, Cyclic AMP Response Element-Binding Protein, Cyclic AMP Response Element Modulator, Cyclic AMP, Binding Sites, Animals, Alternative Splicing, Activating Transcription Factor 1

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          Abstract

          The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?

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          Journal
          11483993
          10.1038/35085068

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