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      Transcriptional regulation by the phosphorylation-dependent factor CREB.

      Nature reviews. Molecular cell biology
      Activating Transcription Factor 1, Alternative Splicing, Animals, Binding Sites, Cyclic AMP, physiology, Cyclic AMP Response Element Modulator, Cyclic AMP Response Element-Binding Protein, chemistry, genetics, Cyclic AMP-Dependent Protein Kinases, DNA Methylation, DNA-Binding Proteins, Gene Expression Regulation, Gene Products, tax, Growth Substances, Human T-lymphotropic virus 1, Leucine Zippers, Macromolecular Substances, Mice, Mice, Knockout, Mice, Transgenic, Models, Genetic, Models, Molecular, Multigene Family, Nuclear Proteins, Phosphorylation, Protein Conformation, Protein Processing, Post-Translational, Regulatory Sequences, Nucleic Acid, Repressor Proteins, Second Messenger Systems, Stress, Physiological, metabolism, Trans-Activators, Transcription Factors, Transcription, Genetic

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          Abstract

          The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?

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