Dengue infection in pregnancy and its impact on the placenta.

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Abstract

A histopathological and immunohistochemical study was conducted in placental tissues and retained products of conception from 24 patients with confirmed dengue infection during pregnancy. The immunohistochemical assay was positive for dengue virus in 19 placental and three ovular remnants analyzed. The light microscopic findings were signs of hypoxia, choriodeciduitis, deciduitis and intervillositis and the viral antigens were found in cytoplasmic of the trophoblast, villous stroma and decidua. Our results suggest that immunohistochemistry could be used as a laboratory confirmation method for dengue in pregnant women, especially in endemic areas when embedded material is the only material available.

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Author and article information

Journal

Journal ID (iso-abbrev): Int. J. Infect. Dis.

Title: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Publisher: Elsevier BV

ISSN (Electronic): 1878-3511

ISSN (Print): 1201-9712

Publication date (Electronic): Feb 2017

Volume: 55

Affiliations

[1 ] Departamento Materno-infantil, Universidade Federal Fluminense, 303, Marquês do Paraná Street, 3° floor, Centro, Niterói, Rio de Janeiro 24033-900, Brazil. Electronic address: chrisribeiro@vm.uff.br.

[2 ] Department of Pathology, Universidade Federal Fluminense, 303, Marquês do Paraná Street, Centro, Niterói, Rio de Janeiro, 24033-900, Brazil. Electronic address: vasilami@oul.com.br.

[3 ] 'Evandro Chagas' National Institute of Infectology [Instituto Nacional de Infectologia Evandro Chagas]/Fiocruz, Rio de Janeiro, Brazil. Electronic address: patricia.brasil@ini.fiocruz.br.

[4 ] Department of Pathology, Universidade Federal Fluminense, 303, Marquês do Paraná Street, Centro, Niterói, Rio de Janeiro, 24033-900, Brazil. Electronic address: andreapires@fontemd.com.br.

[5 ] Intensivist, Head of maternal-fetal intensive care unit of Perinatal de Laranjeiras and Barra da Tijuca, Brazil. Electronic address: roger.rohloff@gmail.com.

[6 ] Flavirus Laboratory, Oswaldo Cruz Institute/Fiocruz, Brazil. Electronic address: rita@ioc.fiocruz.br.

Article

Publisher Item ID: S1201-9712(17)30005-X

DOI: 10.1016/j.ijid.2017.01.002

PubMed ID: 28088588

SO-VID: e1bb2c3a-08bb-493f-a376-ec3f170bd3c7

History

Keywords: dengue,vertical transmission,pregnancy,placenta

Data availability:

Keywords: dengue, vertical transmission, pregnancy, placenta

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