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      Mechanism and regulation of human non-homologous DNA end-joining.

      Nature reviews. Molecular cell biology

      metabolism, DNA Damage, physiology, DNA Repair, Gene Rearrangement, Humans, Nuclear Proteins, Animals

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          Abstract

          Non-homologous DNA end-joining (NHEJ)--the main pathway for repairing double-stranded DNA breaks--functions throughout the cell cycle to repair such lesions. Defects in NHEJ result in marked sensitivity to ionizing radiation and ablation of lymphocytes, which rely on NHEJ to complete the rearrangement of antigen-receptor genes. NHEJ is typically imprecise, a characteristic that is useful for immune diversification in lymphocytes, but which might also contribute to some of the genetic changes that underlie cancer and ageing.

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          Author and article information

          Journal
          14506474
          10.1038/nrm1202

          Chemistry

          metabolism, DNA Damage, physiology, DNA Repair, Gene Rearrangement, Humans, Nuclear Proteins, Animals

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