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      Interactions of drug-metabolizing enzymes with the Chinese herb Psoraleae Fructus

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          Abstract

          Psoraleae Fructus (the dried fruits of Psoralea corylifolia), one of the most frequently used Chinese herbs in Asian countries, has a variety of biological activities. In clinical settings, Psoraleae Fructus or Psoraleae Fructus-related herbal medicines frequently have been used in combination with a number of therapeutic drugs for the treatment of various human diseases, such as leukoderma, rheumatism and dysentery. The use of Psoraleae Fructus in combination with drugs has aroused concern of the potential risks of herb-drug interactions (HDI) or herb-endobiotic interactions (HEI). This article reviews the interactions between human drug-metabolizing enzymes and the constituents of Psoraleae Fructus; the major constituents in Psoraleae Fructus, along with their chemical structures and metabolic pathways are summarized, and the inhibitory and inductive effects of the constituents in Psoraleae Fructus on human drug-metabolizing enzymes (DMEs), including target enzyme(s), its modulatory potency, and mechanisms of action are presented. Collectively, this review summarizes current knowledge of the interactions between the Chinese herb Psoraleae Fructus and therapeutic drugs in an effort to facilitate its rational use in clinical settings, and especially to avoid the potential risks of HDI or HEI through human DMEs.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier BV
          1875-5364
          20 November 2019
          : 17
          : 11
          : 858-870
          Affiliations
          1 Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 200000, China
          2 Translational Medicine Center, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200000, China
          3 Qinghai Hospital of Traditional Chinese Medicine, Xining 810000, China
          Author notes
          *Corresponding author: FANG Sheng-Quan, E-mail: anazrun@ 123456yahoo.com ; GE Guang-Bo, geguangbo@ 123456dicp.ac.cn

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(19)30103-7
          10.1016/S1875-5364(19)30103-7
          31831132
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: NSF of China
          Award ID: 81922070
          Funded by: NSF of China
          Award ID: 81973286
          Funded by: NSF of China
          Award ID: 81773687
          Funded by: National Key Research and Development Program of China
          Award ID: 2017YFC1700200
          Funded by: National Key Research and Development Program of China
          Award ID: 2017YFC1702000
          Funded by: Program of Shanghai Academic/ Technology Research Leader
          Award ID: 18XD1403600
          Funded by: Shuguang Program
          Award ID: 18SG40
          Funded by: Program for applied basic research of Qinghai Provincial Science and Technology Department
          Award ID: 2017-ZJ-713
          Funded by: Program for Innovative Leading Talents of Qinghai Province
          Award ID: 2018 & 2019
          This work was supported by the NSF of China (Nos. 81922070, 81973286, 81773687), the National Key Research and Development Program of China (No. 2017YFC1700200, 2017YFC1702000), Program of Shanghai Academic/ Technology Research Leader (No. 18XD1403600), and Shuguang Program (No. 18SG40), Program for applied basic research of Qinghai Provincial Science and Technology Department (No. 2017-ZJ-713), and Program for Innovative Leading Talents of Qinghai Province (2018 & 2019).
          Categories
          Research article

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