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      Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect.

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          Abstract

          The APOE epsilon4 allele is associated with the risk of late-onset Alzheimer's disease. The age at which memory decline diverges among persons who are homozygous for the APOE epsilon4 allele, those who are heterozygous for the allele, and noncarriers is unknown.

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          Author and article information

          Journal
          N Engl J Med
          The New England journal of medicine
          Massachusetts Medical Society
          1533-4406
          0028-4793
          Jul 16 2009
          : 361
          : 3
          Affiliations
          [1 ] Department of Neurology, Mayo Clinic Arizona, Scottsdale, Arizona 85259, USA. caselli.richard@mayo.edu
          Article
          361/3/255 NIHMS182704
          10.1056/NEJMoa0809437
          2928998
          19605830
          e1fcf96c-5138-4f04-aa04-58681924000a
          2009 Massachusetts Medical Society
          History

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