Francesco Caputo: Role: Writing – original draftRole: Writing – review & editing
Vincenzo Dadduzio: Role: Writing – original draftRole: Writing – review & editing
Francesco Tovoli: Role: Writing – original draftRole: Writing – review & editing
Giulia Bertolini: Role: Writing – original draftRole: Writing – review & editing
Giuseppe Cabibbo: Role: Writing – original draftRole: Writing – review & editing
Krisida Cerma: Role: Writing – original draftRole: Writing – review & editing
Caterina Vivaldi: Role: Writing – original draftRole: Writing – review & editing
Luca Faloppi: Role: Writing – original draftRole: Writing – review & editing
Mario Domenico Rizzato: Role: Writing – original draftRole: Writing – review & editing
Fabio Piscaglia: Role: Writing – original draftRole: Writing – review & editing
Ciro Celsa: Role: Writing – original draftRole: Writing – review & editing
Lorenzo Fornaro: Role: Writing – original draftRole: Writing – review & editing
Giorgia Marisi: Role: Writing – original draftRole: Writing – review & editing
Fabio Conti: Role: Writing – original draftRole: Writing – review & editing
Nicola Silvestris: Role: Writing – original draftRole: Writing – review & editing
Marianna Silletta: Role: Writing – original draftRole: Writing – review & editing
Sara Lonardi: Role: Writing – original draftRole: Writing – review & editing
Alessandro Granito:
ORCID: http://orcid.org/0000-0002-0637-739X
Role: Writing – original draftRole: Writing – review & editing
Caterina Stornello: Role: Writing – original draftRole: Writing – review & editing
Valentina Massa: Role: Writing – original draftRole: Writing – review & editing
Giorgio Astara: Role: Writing – original draftRole: Writing – review & editing
Sabina Delcuratolo: Role: Writing – original draftRole: Writing – review & editing
Stefano Cascinu: Role: Writing – original draftRole: Writing – review & editing
Mario Scartozzi: Role: Writing – original draftRole: Writing – review & editing
Andrea Casadei-Gardini:
ORCID: http://orcid.org/0000-0001-6289-7202
Role: Writing – original draftRole: Writing – review & editing
Matias A. Avila: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
7
May
2020
Publication date Collection: 2020
Volume: 15
Issue: 5
Electronic Location Identifier: e0232449
Affiliations
[1
]
Division of Oncology, Department of Oncology and Hematology, University of Modena
and Reggio Emilia, Modena, Italy
[2
]
Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy
[3
]
Azienda Ospedaliera Universitaria S.Orsola-Malpighi Bologna, Bologna, Italy
[4
]
Medical Oncology Unit IRCSS-IRST Meldola, Meldola, Italy
[5
]
Section of Gastroenterology & Hepatology, PROMISE, University of Palermo, Palermo,
Italy
[6
]
Department of Oncology, University of Pisa, Pisa, Italy
[7
]
Medical Oncology Unit, Macerata General Hospital, Macerata, Italy
[8
]
Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua,
Italy
[9
]
Department of Internal Medicine, Degli Infermi Hospital, Faenza, Italy
[10
]
Medical Oncology Unit, IRCCS Giovanni Paolo II Cancer Center, Bari, Italy
[11
]
Medical Oncology Department, Campus Biomedico, University of Rome, Rome, Italy
[12
]
Digestive and Liver Disease Unit, S. Andrea Hospital, Rome, Italy
[13
]
Department of Medical Oncology, University of Cagliari, Cagliari, Italy
[14
]
Department of Medical Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy
University of Navarra School of Medicine and Center for Applied Medical Research (CIMA),
SPAIN
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-20-08153
DOI: 10.1371/journal.pone.0232449
PMC ID: 7205300
PubMed ID: 32379785
SO-VID: e1fd9798-d987-46ce-a724-4327bb8db6b7
Copyright © © 2020 Caputo et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancers and Neoplasms
Subject:
Carcinomas
Subject:
Hepatocellular Carcinoma
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancers and Neoplasms
Subject:
Gastrointestinal Tumors
Subject:
Hepatocellular Carcinoma
Subject:
Medicine and Health Sciences
Subject:
Gastroenterology and Hepatology
Subject:
Liver Diseases
Subject:
Hepatocellular Carcinoma
Subject:
Research and Analysis Methods
Subject:
Mathematical and Statistical Techniques
Subject:
Statistical Methods
Subject:
Multivariate Analysis
Subject:
Physical Sciences
Subject:
Mathematics
Subject:
Statistics
Subject:
Statistical Methods
Subject:
Multivariate Analysis
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Hepatitis viruses
Subject:
Hepatitis B virus
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Hepatitis viruses
Subject:
Hepatitis B virus
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Hepatitis viruses
Subject:
Hepatitis B virus
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Flaviviruses
Subject:
Hepacivirus
Subject:
Hepatitis C virus
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Flaviviruses
Subject:
Hepacivirus
Subject:
Hepatitis C virus
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Flaviviruses
Subject:
Hepacivirus
Subject:
Hepatitis C virus
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Flaviviruses
Subject:
Hepacivirus
Subject:
Hepatitis C virus
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Hepatitis viruses
Subject:
Hepatitis C virus
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Hepatitis viruses
Subject:
Hepatitis C virus
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Hepatitis viruses
Subject:
Hepatitis C virus
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
Lymphocytes
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Lymphocytes
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Lymphocytes
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Lymphocytes
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancer Treatment
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Etiology
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Albumins
