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      Ebola Hemorrhagic Fever Outbreaks in Gabon, 1994–1997: Epidemiologic and Health Control Issues

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          Abstract

          From the end of 1994 to the beginning of 1995, 49 patients with hemorrhagic symptoms were hospitalized in the Makokou General Hospital in northeastern Gabon. Yellow fever (YF) virus was first diagnosed in serum by use of polymerase chain reaction followed by blotting, and a vaccination campaign was immediately instituted. The epidemic, known as the fall 1994 epidemic, ended 6 weeks later. However, some aspects of this epidemic were atypical of YF infection, so a retrospective check for other etiologic agents was undertaken. Ebola (EBO) virus was found to be present concomitantly with YF virus in the epidemic. Two other epidemics (spring and fall 1996) occurred in the same province. GP and L genes of EBO virus isolates from all three epidemics were partially sequenced, which showed a difference of <0.1% in the base pairs. Sequencing also showed that all isolates were very similar to subtype Zaire EBO virus isolates from the Democratic Republic of the Congo.

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          Author and article information

          Journal
          The Journal of Infectious Diseases
          J INFECT DIS
          University of Chicago Press
          0022-1899
          1537-6613
          February 1999
          February 1999
          : 179
          : s1
          : S65-S75
          Article
          10.1086/514290
          9988167
          e22c7b7a-390f-44b2-ad16-55e3ff7cfa74
          © 1999
          History

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