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      Molecular Screening of Keratoconus Susceptibility Sequence Variants in VSX1, TGFBI, DOCK9, STK24, and IPO5 Genes in Polish Patients and Novel TGFBI Variant Identification.

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          Abstract

          Keratoconus (KTCN) is a degenerative disorder of the eye that results in the conical shape and thinning of the cornea and is a leading cause for corneal transplantations. A number of studies suggest that genetic factors play a role in KTCN etiology. Some candidate gene variants have recently been shown to be associated with KTCN. The purpose of our study was to verify the role of VSX1, TGFBI, DOCK9, IPO5, and STK24 sequence variants in Polish KTCN patients.

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          Author and article information

          Journal
          Ophthalmic Genet.
          Ophthalmic genetics
          Informa UK Limited
          1744-5094
          1381-6810
          2016
          : 37
          : 1
          Affiliations
          [1 ] a Department of Genetics and Pharmaceutical Microbiology , Poznan University of Medical Sciences , Poznan , Poland .
          [2 ] b Institute of Human Genetics, Polish Academy of Sciences , Poznan , Poland , and.
          [3 ] c Department of Ophthalmology , Medical University of Warsaw, SPKSO University Ophthalmic Hospital , Warsaw , Poland.
          Article
          10.3109/13816810.2014.926375
          24940934
          e22f305c-8ad3-4a94-83de-db2c3f80b1ab
          History

          TGFBI,molecular screening,Candidate genes,VSX1,keratoconus
          TGFBI, molecular screening, Candidate genes, VSX1, keratoconus

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