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      The insulin-signaling pathway of the pancreatic islet is impaired in adult mice offspring of mothers fed a high-fat diet.

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          Abstract

          Mothers fed a high-fat (HF) diet can cause different adverse alterations in their offspring. The study aimed to verify the pancreatic islet structure and insulin-signaling pathway in adulthood of offspring of mothers fed a HF diet during the pregnancy.

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          Author and article information

          Journal
          Nutrition
          Nutrition (Burbank, Los Angeles County, Calif.)
          Elsevier BV
          1873-1244
          0899-9007
          Oct 2016
          : 32
          : 10
          Affiliations
          [1 ] Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
          [2 ] Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: Marciaguila@gmail.com.
          Article
          S0899-9007(16)00126-X
          10.1016/j.nut.2016.03.001
          27155954
          e243a946-9c94-4579-a4ec-3c26b9b807a9
          History

          Mice,Insulin signaling,Insulin resistance,Fetal programming,Pancreatic islet

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