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      In vivo and in vitro Absorption of Amino Acids and Dipeptides in the Small Intestine of Uremic Rats

      , ,

      Nephron

      S. Karger AG

      Dipeptide, Glucose, Uremia, Small intestinal absorption, Amino acid

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          Abstract

          The small intestinal absorptive capacity in partially nephrectomized rats was studied in vitro and in vivo. Severe uremia reduced the in vivo uptake of glycine, L-methionine and L-lysine, while the dipeptides glycyl- L-valine, glycyl- L-leucine and glycyl- L-lysine were not similarly affected. The in vitro study using everted rings failed to show any changes in the absorption of amino acids, dipeptides and glucose in uremic rats. The results indicate that in uremia, as in other adverse conditions, the amino acid absorptive step is more severely damaged than that of the dipeptide.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1982
          1982
          03 December 2008
          : 31
          : 3
          : 273-276
          Affiliations
          Renal Unit at the Department of Medicine, and Department of Experimental Research, University Hospital, Malmö, Sweden
          Article
          182659 Nephron 1982;31:273–276
          10.1159/000182659
          6811961
          © 1982 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Dipeptide, Glucose, Uremia, Small intestinal absorption, Amino acid

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