6
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Muscarinic cholinergic receptors (MR3) in saliva of patients with oral lichen planus.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Oral lichen planus (OLP) is a relatively common, chronic, and inflammatory mucocutaneous disease. Xerostomia is also a common complaint of most OLP patients. Considering the significant role of M3 muscarinic receptors (M3R) in secretion of saliva, this study sought to compare the level of this receptor in saliva between OLP patients and healthy controls. Forty OLP patients and 40 healthy controls filled out two questionnaires regarding xerostomia to assess its degree of severity. Unstimulated and stimulated salivary samples were obtained of both groups and the stimulated and unstimulated salivary flow rates were calculated. Salivary level of M3 muscarinic receptors was measured using the ELISA kit. Data were analyzed and compared using unpaired student's t test. P < 0.05 was considered significant. Stimulated and unstimulated salivary flow rates and M3 muscarinic receptors levels were significantly lower but degree of xerostomia was significantly higher in OLP patients compared to healthy controls. Salivary M3 muscarinic receptor seems to be low in the patients with OLP and these patients suffer from xerostomia and reduced salivary flow rate.

          Related collections

          Author and article information

          Journal
          Arch Dermatol Res
          Archives of dermatological research
          Springer Science and Business Media LLC
          1432-069X
          0340-3696
          Sep 2016
          : 308
          : 7
          Affiliations
          [1 ] Dental Research Center, Dental Research Institute & Department of Oral and Maxillo facial Medicine, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. aghahose@sina.tums.ac.ir.
          [2 ] Department of Physiology, School of Medicine, Aja University of Medical Sciences, Tehran, Iran.
          [3 ] Dental Research Center, Dental Research Institute & Department of Oral and Maxillo facial Medicine, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
          Article
          10.1007/s00403-016-1670-7
          10.1007/s00403-016-1670-7
          27371099
          e26d0c15-94f9-4634-8b2b-aa679909de64
          History

          M3 muscarinic receptors,Oral lichen planus,Xerostomia

          Comments

          Comment on this article