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      Radioactive concentration of 131I in the air of treatment workplaces for differentiated thyroid cancer with sodium iodide [ 131I] oral solution

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          Abstract

          Objective To study the radioactive concentration of 131I in the air of workplaces where sodium iodide [ 131I] oral solution was administrated for patients with differentiated thyroid cancer (DTC) in the Department of Nuclear Medicine, and to estimate the internal radiation dose to the staff.

          Methods Workplaces of radioiodine 131I therapy for DTC patients in the Department of Nuclear Medicine of a hospital were investigated. Air samples in 131I administration areas and treatment wards were collected respectively and were measured by low-background gamma-ray spectrometry to calculate the activity concentration of 131I in the air and to further estimate the internal radiation dose to staffs.

          Results The activity concentration in the 131I administration area within the first 3 h of administration was 3~187 Bq/m 3. During administration and within the first 3 h of administration, the staff exposed in the administration area for 5~30 min received an internal radiation dose of 0.08~0.50 μSv and 0.00~0.04 μSv, respectively. The highest activity concentration of 131I in the air of the ward was measured on the day of administration, reaching 3 091 Bq/m 3. After patients were discharged, the activity concentration in the ward gradually decreased to 10~242 Bq/m 3 within 48 h. Within 48 h after patients were discharged, the staff exposed in the ward for 5~30 min received an internal radiation dose of 0.01~14.11 μSv.

          Conclusion A high activity concentration of 131I in the air was recorded during administration for DTC patients in radioiodine 131I therapy, and thus we recommend remote instructed administration or administration through a shielded window. We also recommend that non-treatment related personnel except medical staffs should not enter the ward during patients’ hospitalization at which the activity concentration of 131I in the ward was the highest. After patients were discharged, a delayed entry into the ward is recommended to reduce the internal radiation dose.

          Abstract

          摘要: 目的 研宄核医学科碘 [ 131I] 化钠口服溶液治疗分化型甲状腺癌 (DTC) 患者时, 治疗场所空气中 131I 放射性浓 度, 评估工作人员内照射剂量。 方法 选取某医院核医学科 DTC 患者 131I 住院治疗的工作场所。分别对 131I 服药区和 131I 治疗病房空气进行气体采样, 通过低本底伽玛谱仪探测样本, 经计算空气中 131I 的活度浓度, 估算工作人员受到的 内照射剂量。 结果131I 服药区, 服药 3 h 内活度浓度为 3~187 Bq/m 3。患者服药期间及患者服药后 3 h、在服药处 停留 5~30 min, 内照射剂量分别为 0.08~0.50 μSv 及 0.00~0.04 μSv。患者服药当天病房空气中 131I 的活度浓度最高, 可达 3 091 Bq/m 3; 患者出院后, 病房活度浓度逐渐降低, 在 48 h 内浓度为 10~242 Bq/m 3。出院后 48 h 内在病房停留 5~30 min, 内照射剂量为 0.01~14.11 μSv。 结论 131I 治疗 DTC 患者服药期间空气中 131I 活度浓度较高, 建议采用远 程给药或观察窗给药。患者住院期间, 病房内 131I 活度浓度最高, 建议除医护人员外, 禁止其他人员进入病房。患者出 院后, 尽量延后进入病房的时间, 以减少内照射剂量。

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          Author and article information

          Journal
          CJRH
          Chinese Journal of Radiological Health
          Chinese Preventive Medical Association (Ji’an, China )
          1004-714X
          01 April 2022
          01 April 2022
          : 31
          : 2
          : 197-203
          Affiliations
          [1] 1National Cancer center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116 China
          [2] 2National Cancer center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021 China
          [3] 3Beijing Explore Times Technology Co. Ltd, Beijing 102600 China
          Author notes
          Corresponding authors: GENG Jianhua, E-mail: gengjean@ 123456163.com
          Article
          j.issn.1004-714X.2022.02.012
          10.13491/j.issn.1004-714X.2022.02.012
          e2745c64-fa00-4e57-a603-7dfe4443cb20
          © 2022 Chinese Journal of Radiological Health

          This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 Unported License (CC BY-NC 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc/4.0/.

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          Categories
          Journal Article

          Medicine,Image processing,Radiology & Imaging,Bioinformatics & Computational biology,Health & Social care,Public health
          Internal radiation,Department of nuclear medicine,Radioiodine 131I therapy,Hospitalization,Aerosol,Activity concentration

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