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Iontophoresis on minoxidil sulphate-loaded chitosan nanoparticles accelerates drug release, decreasing their targeting effect to hair follicles

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      Abstract

      The experiments described in this paper tested the hypothesis whether iontophoresis applied on a chitosan nanoparticle formulation could combine the enhanced drug accumulation into the follicular casts obtained using iontophoresis and the sustained drug release, reducing dermal exposure, provided by nanoparticles. Results showed that even though iontophoresis presented comparable minoxidil targeting potential to hair follicles than passive delivery of chitosan-nanoparticles (4.1 ± 0.9 and 5.3 ± 1.0 µg cm-2, respectively), it was less effective on preventing dermal exposure, since chitosan-nanoparticles presented a drug permeation in the receptor solution of 15.3 ± 4.3 µg cm-2 after 6 h of iontophoresis, while drug amounts from passive nanoparticle delivery were not detected. Drug release experiments showed particles were not able to sustain the drug release under the influence of a potential gradient. In conclusion, the application of MXS-loaded chitosan nanoparticles remains the best way to target MXS to the hair follicles while preventing dermal exposure.

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            Author and article information

            Affiliations
            Brasília Distrito Federal orgnameUniversidade de Brasília orgdiv1Faculdade de Ciências da Saúde orgdiv2Departamento de Farmácia Brazil
            Contributors
            Role: ND
            Role: ND
            Role: ND
            Role: ND
            Role: ND
            Role: ND
            Role: ND
            Journal
            qn
            Química Nova
            Quím. Nova
            Sociedade Brasileira de Química (São Paulo, SP, Brazil )
            0100-4042
            1678-7064
            February 2017
            : 40
            : 2
            : 154-157
            S0100-40422017000200154 10.21577/0100-4042.20160159

            This work is licensed under a Creative Commons Attribution 4.0 International License.

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            Figures: 0, Tables: 0, Equations: 0, References: 23, Pages: 4
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            Product Information: SciELO Brazil

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