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      Ethyl pyruvate protects against blood-brain barrier damage and improves long-term neurological outcomes in a rat model of traumatic brain injury.

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          Abstract

          Many traumatic brain injury (TBI) survivors sustain neurological disability and cognitive impairments due to the lack of defined therapies to reduce TBI-induced long-term brain damage. Ethyl pyruvate (EP) has shown neuroprotection in several models of acute brain injury. The present study therefore investigated the potential beneficial effect of EP on long-term outcomes after TBI and the underlying mechanisms.

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          Author and article information

          Journal
          CNS Neurosci Ther
          CNS neuroscience & therapeutics
          1755-5949
          1755-5930
          Apr 2015
          : 21
          : 4
          Affiliations
          [1 ] Department of Anesthesiology of Huashan Hospital, State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China; Department of Anesthesiology of Shanghai Pulmonary Hospital, Tongji University, Shanghai, China.
          Article
          NIHMS640813
          10.1111/cns.12366
          4376651
          25533312
          © 2014 John Wiley & Sons Ltd.

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