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      Sites of the Negative Feedback Action of Corticosteroids on the Hypothalamo-Hypophysial System of the Rat Fetus

      Neuroendocrinology

      S. Karger AG

      Corticosterone, Dexamethasone, Feedback, Metyrapone, Deoxycorticosterone, Fetus, Hypothalamus, Pituitary

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          Abstract

          Dexamethasone, corticosterone and deoxycorticos-terone were given to intact, encephalectomized or decapitated rat fetuses from mothers treated with metyrapone, in order to deter-mine the location of the sites of the negative feedback action of corticosteroids. The corticosterone concentration dropped in the adrenals and plasma of intact fetuses, measured on the 22nd day of pregnancy (21-day-old fetuses), after metyrapone (30 mg) had been given to the mothers on the 21st day of pregnancy (20-day-old fetuses). Adrenal hypertrophy was observed in intact (35%) and encephalectomized (18%) but not in decapitated fetuses. Corticosterone acetate (100 µg) prevented adrenal hypertrophy in both intact and encephalectomized fetuses. Dexamethasone acetate (125 µg) prevented adrenal hypertrophy only in the intact fetuses. A high level of deoxycorticosterone acetate (600 µg) also prevented adrenal hypertrophy. These results are discussed. These data suggest that the pituitary as well as the hypothalamus and/or the upper nervous structures contain sites sensitive to the negative feedback action of corticosterone. They also point toward a hypothalamic site of action of dexamethasone.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1974
          1974
          20 March 2008
          : 16
          : 3-4
          : 148-155
          Affiliations
          Laboratoire de Physiologie Comparée, Université de Paris VI, Paris
          Article
          122561 Neuroendocrinology 1974;16:148–155
          10.1159/000122561
          4449584
          © 1974 S. Karger AG, Basel

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          Page count
          Pages: 8
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          Paper

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