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      Obesity-linked diabetes in the Arab world: a review.

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          Abstract

          The Arab world is experiencing an epidemic of obesity and type 2 diabetes mellitus. This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. There are alarming data related to the rising prevalence of obesity and type 2 diabetes mellitus in children of Arab ethnicity. Replication studies identify several genetic variants in Arabs with obesitylinked diabetes. For example, variants of the ADIPOQ gene (the rs266729 single-nucleotide polymorphism) are associated with obesity and diabetes in various Arab countries. Gaps exist in our information about diabetes and obesity in Arab populations in relation to ethnic-specific cut-off points for diagnosis and treatment of diabetes. Further genome-wide association studies in obese and diabetic Arab populations could add to our understanding of the pathophysiology, prevention and reversal of this disease.

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          Author and article information

          Journal
          East Mediterr Health J
          Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
          World Health Organization Regional Office for the Eastern Mediterranean (WHO/EMRO)
          1020-3397
          1020-3397
          Sep 08 2015
          : 21
          : 6
          Affiliations
          [1 ] Department of Pharmacology and Therapeutics, Faculty of Medicine, Vancouver, British Columbia, Canada.
          Article
          10.26719/2015.21.420
          26370001
          e27efa7d-c970-4499-b17c-461b7e25b3ae
          History

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