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      Caloric restriction delays disease onset and mortality in rhesus monkeys.

      Science (New York, N.Y.)

      prevention & control, epidemiology, Neoplasms, Male, Macaca mulatta, Longevity, Incidence, metabolism, Glucose, Female, Diabetes Mellitus, Cardiovascular Diseases, Caloric Restriction, pathology, Brain, Body Weight, Atrophy, Animals, Aging

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          Abstract

          Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging-related deaths. At the time point reported, 50% of control fed animals survived as compared with 80% of the CR animals. Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species.

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          Journal
          19590001
          2812811
          10.1126/science.1173635

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