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      Comparison of Estrogen Priming Effects with Body Weight Restoration Effects on the Gonadotropin Pattern of Patients with Anorexia nervosa

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          Plasma estradiol (E<sub>2</sub>), serum LH and FSH, and the gonadotropin response to two consecutive LHRH administrations (10 and 100 µg with an interval of 2 h) were determined in 19 patients with anorexia nervosa (AN) at the emaciation phase, before and after estradiol benzoate (E<sub>2</sub>B) injections (3 µg/kg/day for 7 days). The same investigations were repeated after weight restoration in 9 AN atients who remained amenorrheic. Both at the emaciation phase and after weight restoration, E<sub>2</sub>B enhanced the second LH response to LHRH and decreased serum FSH, suggesting that the functional capacities of the pituitary gonadotrophs are normal in AN. Unlike E<sub>2</sub>B injections, weight restoration increased all the hormone values, suggesting that the weight restoration effects on the abnormal gonadotropin secretory pattern of AN depend on another mechanism than the E<sub>2</sub> lowering. That mechanism is probably a disorder of the hypothalamic LHRH secretion, the consequences of which could be reinforced by the low E<sub>2</sub> levels.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          26 November 2008
          : 20
          : 4
          : 224-230
          Service d’Endocrinologie et de Diabétologie (Pr. P. Fossati), Centre Hospitalier Universitaire, Lille, France
          180001 Horm Res 1984;20:224–230
          © 1984 S. Karger AG, Basel

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          Pages: 7


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