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      A consensus on the diagnosis and treatment of acromegaly complications

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          Abstract

          In March 2011, the Acromegaly Consensus Group met to revise and update the guidelines on the diagnosis and treatment of acromegaly complications. The meeting was sponsored by the Pituitary Society and the European Neuroendocrinology Association and included experts skilled in the management of acromegaly. Complications considered included cardiovascular, endocrine and metabolic, sleep apnea, bone diseases, and mortality. Outcomes in selected, related clinical conditions were also considered, and included pregnancy, familial acromegaly and invasive macroadenomas. The need for a new disease staging model was considered, and design of such a tool was proposed.

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          Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology.

          In the United States, colorectal cancer (CRC) is the third most common cancer diagnosed among men and women and the second leading cause of death from cancer. CRC largely can be prevented by the detection and removal of adenomatous polyps, and survival is significantly better when CRC is diagnosed while still localized. In 2006 to 2007, the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology came together to develop consensus guidelines for the detection of adenomatous polyps and CRC in asymptomatic average-risk adults. In this update of each organization's guidelines, screening tests are grouped into those that primarily detect cancer early and those that can detect cancer early and also can detect adenomatous polyps, thus providing a greater potential for prevention through polypectomy. When possible, clinicians should make patients aware of the full range of screening options, but at a minimum they should be prepared to offer patients a choice between a screening test that primarily is effective at early cancer detection and a screening test that is effective at both early cancer detection and cancer prevention through the detection and removal of polyps. It is the strong opinion of these 3 organizations that colon cancer prevention should be the primary goal of screening.
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            Medical progress: Acromegaly.

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              Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline.

              Our objective was to develop clinical practice guidelines for the diagnosis and treatment of patients with primary aldosteronism. The Task Force comprised a chair, selected by the Clinical Guidelines Subcommittee (CGS) of The Endocrine Society, six additional experts, one methodologist, and a medical writer. The Task Force received no corporate funding or remuneration. Systematic reviews of available evidence were used to formulate the key treatment and prevention recommendations. We used the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) group criteria to describe both the quality of evidence and the strength of recommendations. We used "recommend" for strong recommendations and "suggest" for weak recommendations. Consensus was guided by systematic reviews of evidence and discussions during one group meeting, several conference calls, and multiple e-mail communications. The drafts prepared by the task force with the help of a medical writer were reviewed successively by The Endocrine Society's CGS, Clinical Affairs Core Committee (CACC), and Council. The version approved by the CGS and CACC was placed on The Endocrine Society's Web site for comments by members. At each stage of review, the Task Force received written comments and incorporated needed changes. We recommend case detection of primary aldosteronism be sought in higher risk groups of hypertensive patients and those with hypokalemia by determining the aldosterone-renin ratio under standard conditions and that the condition be confirmed/excluded by one of four commonly used confirmatory tests. We recommend that all patients with primary aldosteronism undergo adrenal computed tomography as the initial study in subtype testing and to exclude adrenocortical carcinoma. We recommend the presence of a unilateral form of primary aldosteronism should be established/excluded by bilateral adrenal venous sampling by an experienced radiologist and, where present, optimally treated by laparoscopic adrenalectomy. We recommend that patients with bilateral adrenal hyperplasia, or those unsuitable for surgery, optimally be treated medically by mineralocorticoid receptor antagonists.
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                Author and article information

                Contributors
                Shlomo.Melmed@cshs.org
                Journal
                Pituitary
                Pituitary
                Pituitary
                Springer US (Boston )
                1386-341X
                1573-7403
                18 August 2012
                18 August 2012
                2013
                : 16
                : 3
                : 294-302
                Affiliations
                [ ]Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Room 2015, Los Angeles, CA 90048 USA
                [ ]Division of Endocrinology CHUS, Department of Medicine, Santiago de Compostela University, Santiago de Compostela, Spain
                [ ]Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA
                [ ]Neuroendocrine Unit, Division of Endocrinology and Metabolism, University of Sao Paulo Medical School, Sao Paulo, Brazil
                [ ]Faculté de Médecine, Université Paris Sud, Orsay, France
                [ ]AP-HP, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre, France
                [ ]Institut National de la Santé et de la Recherche Médicale, U693, Le Kremlin Bicêtre, France
                [ ]Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Centre, Rotterdam, The Netherlands
                [ ]Department of Endocrinology, Charite Campus Mitte, Berlin, Germany
                [ ]Department of Endocrinology, Oxford Centre of Diabetes, Endocrinology & Metabolism, Churchill Hospital, Oxford, UK
                [ ]Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
                Article
                420
                10.1007/s11102-012-0420-x
                3730092
                22903574
                e2d33977-7767-4be9-9a2f-45628b04147d
                © The Author(s) 2012
                History
                Categories
                Article
                Custom metadata
                © Springer Science+Business Media New York 2013

                Medicine
                acromegaly,consensus,complications,diagnosis,treatment
                Medicine
                acromegaly, consensus, complications, diagnosis, treatment

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