Nesprin-2G tension fine-tunes Wnt/β-catenin signaling

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Abstract

Gottardi and Luxton preview work from the Borghi laboratory implicating LINC complex proteins as mechanotransducers that fine-tune Wnt/β-catenin signaling during epithelial–mesenchymal transition.

Abstract

How LINC complexes mediate nuclear mechanotransduction remains unclear. In this issue, Déjardin, Carollo, et al. (2020. J. Cell Biol. https://doi.org/10.1083/jcb.201908036) show that the LINC complex protein nesprin-2G is a mechanosensor of epithelial–mesenchymal transitions (EMTs), recruiting α-catenin to the nucleus to attenuate Wnt/β-catenin signaling.

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Journal

Journal ID (nlm-ta): J Cell Biol

Journal ID (iso-abbrev): J Cell Biol

Journal ID (publisher-id): jcb

Title: The Journal of Cell Biology

Publisher: Rockefeller University Press

ISSN (Print): 0021-9525

ISSN (Electronic): 1540-8140

Publication date Collection: 05 October 2020

Publication date (Electronic): 23 September 2020

Volume: 219

Issue: 10

Electronic Location Identifier: e202009042

Affiliations

[1 ]Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL

[2 ]Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL

[3 ]Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA

Author notes

Correspondence to G.W. Gant Luxton: ggluxton@ 123456ucdavis.edu

Cara J. Gottardi: c-gottardi@ 123456northwestern.edu

[*]

C.J. Gottardi and G.W.G. Luxton contributed equally to this paper.

Author information

Cara J. Gottardi https://orcid.org/0000-0003-0912-7617

G.W. Gant Luxton https://orcid.org/0000-0002-6180-8906

Article

Publisher ID: jcb.202009042

DOI: 10.1083/jcb.202009042

PMC ID: 7659724

PubMed ID: 32966550

SO-VID: e2d68f40-2b4a-4632-9aa7-48c263892079

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This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Page count

Pages: 2

Funding

Funded by: National Institutes of Health, DOI http://dx.doi.org/10.13039/100000002;

Award ID: GM129312

Award ID: HL13480

Funded by: National Institutes of Health, DOI http://dx.doi.org/10.13039/100000002;

Award ID: GM129374

Funded by: Gordon and Betty Moore Foundation, DOI http://dx.doi.org/10.13039/100000936;

Award ID: 9162.16

Nesprin-2G tension fine-tunes Wnt/β-catenin signaling

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Neuronal Signaling

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