Editor,
The coronavirus disease 2019 (COVID‐19) pandemic is caused by rapid spread of different
strains of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). The severity
of infection ranges from mild, or even asymptomatic, to very severe. Signs and symptoms
include fatigue, fever, exanthemas, upper respiratory illness, loss of smell and taste,
pneumonia, severe acute respiratory syndrome and multi‐organ failure. Risk factors
for a severe or lethal course include age, male gender, obesity, diabetes, cardiovascular
disease and immune suppression.
1
At the start of the pandemic, the European Task Force on Atopic Dermatitis (ETFAD)
shared their position on continuation of systemic immune‐modulating treatments, including
immunosuppressive therapy, in atopic dermatitis (AD) patients during the time of the
pandemic.
2
Safe and effective vaccines are urgently needed to control the pandemic and achieve
herd immunity. More than 50 COVID‐19 vaccine candidates are currently in trials. mRNA
vaccines lead to production of antigens by host cells, and two (RNA‐1273 and BNT162b2)
were recently approved in EU member states to vaccinate adults against COVID‐19. A
viral vector‐based vaccine (AZD1222) has been approved in the United Kingdom, but
not yet in the EU.
National strategic guidelines and recommendations are being developed and utilized
to vaccinate initially those with increased risk factors for a severe course, as well
as those being employed in critical positions. This article provides the position
of ETFAD members regarding COVID‐19 vaccination of adult patients with AD being treated
with systemic immunosuppressive medication and biologics. A separate article discusses
how dermatologist may manage allergic issues. Vaccination particularly against pneumococcus
and influenza should be performed as recommended in the guidelines.
3
The ETFAD acknowledges that.
There is currently no evidence to suggest that AD is an independent risk factor for
acquiring SARS‐CoV‐2, or of having a more severe course of COVID‐19, above and beyond
other important co‐morbid conditions, such as obesity, cardiovascular disease and
diabetes.
Atopic dermatitis is not a contraindication to vaccination. It is unclear whether
SARS‐CoV‐2 vaccination could cause brief AD worsening, but this is not suspected since
the vaccination response is mainly T helper cell 1 skewed.
4
Systemic immunosuppressants and JAK‐inhibitors used to treat AD may attenuate the
vaccination response,
5
but no attenuation is expected for dupilumab.
6
Based on the listed uncertainties and AD disease characteristics,
3
,
7
the risk–benefit ratio of all currently approved vaccines appears better than the
risk of an infection with SARS‐CoV‐2, also for AD patients. There is no clear evidence
to recommend that systemic AD medication is paused before or after COVID‐19 vaccination.
Temporary 2‐week discontinuation of methotrexate slightly improved the immunogenicity
of seasonal influenza vaccination in patients with rheumatoid arthritis,
5
but this may not be relevant to mRNA‐based vaccines. Clinicians may, therefore, consider
pausing immunosuppressant possible during vaccination, typically from the vaccination
day until 1 week after for JAK‐inhibitors and cyclosporine, or until 2 weeks after
for methotrexate and azathioprine, to possibly improve chances or appropriate vaccination
response. Alternatively, the lowest dose possible may be used, for example 2.5 mg/kg/day
cyclosporine, 1 mg/kg/day azathioprine and 7.5 mg/week methotrexate. The ETFAD recommends
to strictly follow guidelines and decisions issued by the local and national health
authorities in each country. While patients on immunosuppressive drugs for AD will
need a case‐by‐case approach considering the specific drug and vaccine product, inadequate
antibody response in selected individuals is not a major concern, and the risk/benefit
of vaccination is considered favourable for the overall AD population. At least 3 weeks
are recommended between the two COVID‐19 vaccine doses, which increases the risk of
AD flares and loss of AD control if the systemic AD medication is paused or reduced
in dose for longer periods. Measurement of antibodies against SARS‐CoV‐2 can be done
in cases with particular importance of successful immunization. If a live vaccine
against COVID‐19 is registered in the future, our recommendations for the use of this
vaccine may be different. We encourage registration of COVID‐19 AD patients in the
ETFAD‐supported SECURE‐AD register (www.secure‐derm.com), which also captures AD patients'
experiences of SARS‐CoV‐2 vaccination.
8
Funding sources
No funding was obtained for this work.
Conflicts of interest
Dr. Thyssen has attended advisory boards for Eli Lilly, Regeneron, Pfizer, LEO Pharma,
Abbvie and Sanofi‐Genzyme, received speaker honorarium from LEO Pharma, Abbvie, Regeneron
and Sanofi‐Genzyme, and received research grants from Regeneron and Sanofi‐Genzyme.
Dr. Vestergaard has been investigator, speaker or consultant for Novartis, Abbvie,
Sanofi, Leo Pharma and Eli Lilly. Dr Barbarot has been a principal investigator, advisory
board member or consultant for Pierre Fabre Laboratory, Bioderma, Laboratoire La Roche
Posay, Sanofi‐Genzyme, Abbvie, Novartis, Janssen, Leo Pharma, Pfizer, Amgen, Lilly.
Dr. de Bruin‐Weller has been a consultant, advisory board member and/or speaker for
AbbVie, Almirall, Arena, Eli Lilly, Galderma, Janssen, Leo Pharma, Pfizer, Regeneron
and Sanofi‐Genzym. Dr. Bieber has been a principal investigator, advisory board member
or consultant for Regeneron, Sanofi, GSK, Celgene, Abbvie, AnaptysBio, MedImmune,
Chugai, Pierre Fabre, Novartis, Asana Biosciences, LEO, Galapagos/MorphoSys, BioVerSys,
Galderma, Kymab, Glenmark, Astellas, Daiichi‐Sankyo, Lilly, Pfizer, MenloTx, Dermavant
and Allmiral. Dr. T. Bieber was speaker, and/or consultant and/or Investigator for
AbbVie, Allmiral, AnaptysBio, Arena, Asana Biosciences, Astellas, BioVerSys, Böhringer‐Ingelheim,
Celgene, Daichi‐Sankyo, Dermavant/Roivant, DermTreat, DS Pharma, RAPT/FLX Bio, Galapagos/MorphoSys,
Galderma, Glenmark, GSK, Incyte, Kymab, LEO, Lilly, L´Oréal, MenloTx, Novartis, Pfizer,
Pierre Fabre, Sanofi/Regeneron, UCB. T. Bieber is founder of the non‐profit biotech
company ‘Davos Biosciences’. Dr. Gutermuth has been a consultant, advisory board member
and/or speaker for AbbVie, Almirall, Eli Lilly, Galderma, Janssen, Leo Pharma, Pfizer,
Regeneron and Sanofi‐Genzyme. Dr Taïeb has been consultant or investigator for Pierre
Fabre, Galderma, Novartis, Johnson and Johnson, Incyte, Abbvie, Modilac, Pfizer, Lilly,
Arena, Bioderma and Sanofi. Dr. Seneschal has been investigator, speaker, or consultant
for Novartis, Abbvie, Sanofi, Leo Pharma and Eli Lilly. Dr. Weidinger has received
institutional research grants from LEO Pharma and L'Oreal, has performed consultancies
for Sanofi‐Genzyme, Regeneron, LEO Pharma, Incyte, Lilly, Abbvie and Novartis, has
lectured at educational events sponsored by Sanofi‐Genzyme, Regeneron, LEO Pharma,
Abbvie and Galderma, and is involved in performing clinical trials with pharmaceutical
industries that manufacture drugs used for the treatment of atopic dermatitis. Dr.
Trzeciak has been a speaker, consultant, investigator or advisory board member for
LEO Pharma, Pierre Fabre, Pfizer, La Roche Posay, Sanofi‐Genzyme, Novartis, Bioderma
and Mead Johnson. Dr. Cork is an Investigator and/or consultant Consultant for Regeneron,
Sanofi‐Genzyme, Pfizer, LEO, Galapagos, Novartis, Boots, L'Oreal, Reckitt Benckiser,
Oxagen, Johnson&Johnson, Hyphens, Kymab, Astellas, Galderma, Procter&Gamble, Abbvie,
Lilly, Galderma, Menlo and Perrigo. Dr. Paul has received grants and been consultant
for Allmiral, Amgen, Abbvie, Boehringer, Celgene, Eli Lilly & Co, Novartis, Janssen,
Pfizer, LEO Pharma, Merck, UCB pharma, Pierre Fabre, Regeneron and Sanofi‐Genzyme.
Dr. Flohr is chief investigator of the UK National Institute for Health Research‐funded
TREAT (ISRCTN15837754) and SOFTER (Clinicaltrials.gov: NCT03270566) trials as well
as the UK‐Irish Atopic eczema Systemic Therapy Register (A‐STAR; ISRCTN11210918) and
a principal investigator in the European Union Horizon 2020‐funded BIOMAP Consortium
(http://www.biomap‐imi.eu/). His department has also received investigator‐led funding
from Sanofi‐Genzyme. Dr. Heratizadeh reports personal fees from Leo Pharma, personal
fees from Novartis, personal fees from Pierre Fabre, personal fees from Sanofi‐Genzyme,
personal fees from Beiersdorf, personal fees from Hans Karrer, personal fees from
Nutricia, personal fees from Meda, personal fees from Lilly, grants from Janssen,
outside the submitted work. Dr. Darsow gave advice to or received an honorarium for
talks or research grant from the following companies: ALK‐Abello, Bencard, Meda, Novartis
and Sanofi‐Regeneron outside the submitted work. Dr. Simon has been an investigator,
advisory board member, or consultant for AbbVie, AstraZeneca, Galderma, Lilly, Pfizer,
Roche Pharma, and Sanofi‐Genzyme. Dr. Torrelo has acted as advisor and/or participant
in clinical trials for Sanofi, Lilly, Pfizer, Abbvie and Mylan. Dr. Gelmetti has acted
as advisor and/or participant in clinical trials for: Bayer, Sanofi/Regeneron, Galderma
and has lectured at educational events sponsored by Pfizer and Leo Pharma. Dr Szalai
has performed consultancies for Sanofi‐Genzyme, Regeneron, LEO Pharma, Novartis, has
lectured at educational events sponsored by Nutricia, is involved in performing clinical
trials with pharmaceutical industries that manufacture drugs used for the treatment
of psoriasis and atopic dermatitis. Dr. von Kobyletzki has been investigator, speaker,
or consultant for Pfizer, Sanofi, Leo Pharma and Eli Lilly. Dr. De Raeve is a consultant,
member of scientific advisory boards and/ or received personal fees and non‐financial
support from LEO Pharma, Pierre Fabre, Sanofi‐Genzyme and Bioderma. Dr. Fölster‐Holst
reports being consultant/Advisor for Beiersdorf AG, Johnson&Johnson, LEO Pharma, Neubourg,
Novartis Pharma AG, Nutricia, Pfizer Inc., Regeneron, Sanofi‐Aventis as well as speaker
for Beiersdorf AG, LEO Pharma, Neubourg, Novartis Pharma AG, Pierre Fabre Laboratories,
Pfizer, Procter&Gamble, Regeneron and Sanofi‐Aventis. Dr Christen‐Zaechs has been
an advisor, speaker or investigator for Galderma, L'Oreal, La Roche Posey, Pierre
Fabre, Procter and Gamble and Sanofi‐Genzyme. Dr. Hijnen has been investigator, speaker,
or consultant for Abbvie, Eli Lilly, Incyte, Leo Pharma, MedImmune/Astrazeneca, Pfizer,
Sanofi and Thermo Fisher. Dr. Gieler has received institutional research grants from
Galderma, has performed consultancies for Sanofi‐Genzyme, Regeneron, LEO Pharma, Lilly,
Abbvie and Novartis, has lectured at educational events sponsored by Sanofi‐Genzyme,
Abbvie, Novartis, Sebamed and Galderma, and is involved in the organization of atopic
dermatitis education programmes in Germany for the treatment of atopic dermatitis.
Dr. Bangert has been consultant or speaker for Bayer, Mylan, LEO Pharma, Pfizer, Sanofi‐Genzyme,
Eli Lilly, Novartis, Celgene and AbbVie and principal investigator for Merck, Novartis,
Sanofi, Abbvie, Elli Lilly and Galderma. Dr. Spuls has done consultancies in the past
for Sanofi 111017 and AbbVie 041217 (unpaid), received departmental independent research
grants from pharmaceutical industries different since December 2019 for the TREAT
NL registry, is involved in performing clinical trials with many pharmaceutical industries
that manufacture drugs used for the treatment of e.g. psoriasis and atopic dermatitis,
for which financial compensation is paid to the department/hospital and, is Chief
Investigator (CI) of the systemic and phototherapy atopic eczema registry (TREAT NL)
for adults and children and one of the main investigator of the SECURE‐AD registry.
Dr. Ring has been an advisor or speaker for AbbVie, Allergika, Sanofi‐Genzyme, Pfizer,
Bencard, LEO Pharma and Mylan. Dr. Wollenberg has been a principal investigator, advisory
board member, or consultant for AbbVie, Almirall, Galderma, Hans Karrer, LEO Pharma,
Lilly, MedImmune, Novartis, Pfizer, Regeneron Pharmaceuticals, Inc. and Sanofi‐Genzyme,
and received speaker honoraria from Chugai, Galderma, LEO Pharma, Lilly, Loreal, MedImmune,
Pfizer, Pierre Fabre, Regeneron Pharmaceuticals, Inc. and Sanofi‐Genzyme. Dr. Deleuran
has been a principal investigator, speaker, advisory board member, and/or consultant
for LEO Pharma, AbbVie, Almirall, Lilly, Novartis, Pfizer, Regeneron Pharmaceuticals,
Inc., Sanofi‐Genzyme and Pierre Fabre. This research was performed independently through
the authors' academic university and hospital affiliations. Dr. Chernyshov, Dr. Stalder,
Dr. Svensson, Dr. Kunz reports no conflict of interest.