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      Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system.

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          Abstract

          Nicotinic receptors - a family of ligand-gated ion channels that mediate the effects of the neurotransmitter acetylcholine - are among the most well understood allosteric membrane proteins from a structural and functional perspective. There is also considerable interest in modulating nicotinic receptors to treat nervous-system disorders such as Alzheimer's disease, schizophrenia, depression, attention deficit hyperactivity disorder and tobacco addiction. This article describes both recent advances in our understanding of the assembly, activity and conformational transitions of nicotinic receptors, as well as developments in the therapeutic application of nicotinic receptor ligands, with the aim of aiding novel drug discovery by bridging the gap between these two rapidly developing fields.

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          Author and article information

          Journal
          Nat Rev Drug Discov
          Nature reviews. Drug discovery
          Springer Science and Business Media LLC
          1474-1784
          1474-1776
          Sep 2009
          : 8
          : 9
          Affiliations
          [1 ] Laboratoire de Chimie Biophysique, Institut de Science et d'Ingénierie Supramoléculaires, UMR 7006 (CNRS-Université de Strasbourg), 8 Allée Gaspard Monge, 67000 Strasbourg, France. a.taly@isis.u-strasbg.fr
          Article
          nrd2927
          10.1038/nrd2927
          19721446
          e2eab9d0-0fbe-45fb-9282-2d65461dcb40
          History

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