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      The relationship between sexual abuse and interstitial cystitis/painful bladder syndrome.

      1 ,
      Current urology reports

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          Abstract

          Interstitial cystitis/painful bladder syndrome (IC/PBS) is a chronic syndrome characterized by irritative voiding symptoms and pelvic pain or discomfort. IC/PBS represents localized bladder pathophysiologic changes and central nervous system upregulation. Patients exhibit bladder hyperalgesia and allodynia. Childhood sexual abuse occurs in up to 27% of females in the United States. Adults with a prior history of abuse or traumatization demonstrate hypothalamic-pituitary-adrenal (HPA) axis abnormalities, similar to IC/PBS patients. Childhood sexual abuse and physical traumatization are associated with subsequent lifelong risks of chronic pain syndromes. IC/PBS patients have increased rates of sexual abuse or physical traumatization histories compared with controls. IC/PBS patients with abuse histories tend to have greater pain intensity and lesser irritative voiding symptoms compared with nonabused IC/PBS patients. This article reviews the relationship between sexual abuse, HPA axis abnormalities, IC/PBS pathophysiology, and the role of sexual abuse on subsequent IC/PBS.

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          Author and article information

          Journal
          Curr Urol Rep
          Current urology reports
          1534-6285
          1527-2737
          Nov 2009
          : 10
          : 6
          Affiliations
          [1 ] Division of Urology, St. Paul's Hospital, Burrard Building C307, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada.
          Article
          10.1007/s11934-009-0070-3
          19863855
          e2f76fbd-70f5-4b24-8e1b-128ff9845554
          History

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