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      ANTI-VIRAL EFFECTS OF MEDICINAL PLANTS IN THE MANAGEMENT OF DENGUE: A SYSTEMATIC REVIEW

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          Abstract

          Background:

          Dengue is considered as an important arboviral disease. Safe, low-cost, and effective drugs that possess inhibitory activity against dengue virus (DENV) are mostly needed to try to combat the dengue infection worldwide. Medicinal plants have been considered as an important alternative to manage several diseases, such as dengue. As authors have demonstrated the antiviral effect of medicinal plants against DENV, the aim of this study was to review systematically the published research concerning the use of medicinal plants in the management of dengue using the PubMed database.

          Materials and Methods:

          Search and selection of publications were made using the PubMed database following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA statement).

          Results:

          Six publications met the inclusion criteria and were included in the final selection after thorough analysis.

          Conclusion:

          It is suggested that medicinal plants’ products could be used as potential anti-DENV agents.

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          Most cited references26

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          The global emergence/resurgence of arboviral diseases as public health problems.

          Duane J. Gubler (2002)
          During the past 20 years there has been a dramatic resurgence or emergence of epidemic arboviral diseases affecting both humans and domestic animals. These epidemics have been caused primarily by viruses thought to be under control such as dengue, Japanese encephalitis, yellow fever, and Venezuelan equine encephalitis, or viruses that have expanded their geographic distribution such as West Nile and Rift Valley fever. Several of these viruses are presented as case studies to illustrate the changing epidemiology. The factors responsible for the dramatic resurgence of arboviral diseases in the waning years of the 20th century are discussed, as is the need for rebuilding the public health infrastructure to deal with epidemic vector-borne diseases in the 21st century.
          Article 0 comments Cited 278 times – based on 0 reviews     Review now
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            Evolutionary relationships of endemic/epidemic and sylvatic dengue viruses.

            Stephanie S. Watowich, Walter Gubler, H. Q. Ni … (2000)
            Endemic/epidemic dengue viruses (DEN) that are transmitted among humans by the mosquito vectors Aedes aegypti and Aedes albopictus are hypothesized to have evolved from sylvatic DEN strains that are transmitted among nonhuman primates in West Africa and Malaysia by other Aedes mosquitoes. We tested this hypothesis with phylogenetic studies using envelope protein gene sequences of both endemic/epidemic and sylvatic strains. The basal position of sylvatic lineages of DEN-1, -2, and -4 suggested that the endemic/epidemic lineages of these three DEN serotypes evolved independently from sylvatic progenitors. Time estimates for evolution of the endemic/epidemic forms ranged from 100 to 1,500 years ago, and the evolution of endemic/epidemic forms represents relatively recent events in the history of DEN evolution. Analysis of envelope protein amino acid changes predicted to have accompanied endemic/epidemic emergence suggested a role for domain III in adaptation to new mosquito and/or human hosts.
            Article 0 comments Cited 105 times – based on 0 reviews     Review now
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              Update on the global spread of dengue.

              Alfonso Guzman, Raul Isturiz (2010)
              The global spread of dengue fever within and beyond the usual tropical boundaries threatens a large percentage of the world's population, as human and environmental conditions for persistence and even spread are present in all continents. The disease causes great human suffering, a sizable mortality from dengue haemorrhagic fever and its complications, and major costs. This situation has worsened in the recent past and may continue to do so in the future. Efforts to decrease transmission by vector control have failed, and no effective antiviral treatment is available or foreseeable on the immediate horizon. A safe and effective vaccine protective against all serotypes of dengue viruses is sorely needed. Copyright © 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
              Article 0 comments Cited 69 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Afr J Tradit Complement Altern Med
                Journal ID (iso-abbrev): Afr J Tradit Complement Altern Med
                Journal ID (publisher-id): AJTCAM
                Title: African Journal of Traditional, Complementary, and Alternative Medicines
                Publisher: African Traditional Herbal Medicine Supporters Initiative (ATHMSI) (Nigeria )
                ISSN (Print): 0189-6016
                ISSN (Electronic): 2505-0044
                Publication date Collection: 2017
                Publication date (Electronic): 07 July 2017
                Volume: 14
                Issue: 4 Suppl
                Pages: 33-40
                Affiliations
                [1 ]Programa de Pós-graduação em Biociências, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 20551-030, RJ, Brasil
                [2 ]Programa de Pós-Graduação em Ciências Médicas, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 20551-030, RJ, Brasil
                [3 ]Programa de Pós-Graduação em Fisiopatologia Clínica e Experimental, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 20551-030, RJ, Brasil
                [4 ]Laboratório de Vibrações Mecânicas e Práticas Integrativas e Complementares, Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 20551-030, RJ, Brasil
                [5 ]Mestrado Profissional em Saúde, Medicina Laboratorial e Tecnologia Forense, Universidade do Estado do Rio de Janeiro, Instituto de Biologia Roberto Alcantara Gomes, Av. Marechal Rondon, Rio de Janeiro, 20950-003, RJ, Brasil
                Author notes
                [* ] Corresponding Author E-mail Address: ericfrederico@ 123456msn.com
                Article
                Publisher ID: AJTCAM-14-33
                DOI: 10.21010/ajtcam.v14i4S.5
                PMC ID: 5514443
                PubMed ID: 28740942
                SO-VID: e2fbad78-e2d5-4dad-b9f3-28bb668cf043
                Copyright © Copyright: © 2017 Afr. J. Traditional Complementary and Alternative Medicines
                License:

                This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License

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                Subject: Article

                Keywords: dengue,arbovirus,medicinal plants,pubmed
                Data availability:
                Keywords: dengue, arbovirus, medicinal plants, pubmed

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