22
views
0
recommends
+1 Recommend
2 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Caring for people with heart failure and many other medical problems through and beyond the COVID‐19 pandemic: the advantages of universal access to home telemonitoring

      editorial

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          This article refers to ‘Telemonitoring versus standard care in heart failure: a randomised multicentre trial’ by M. Galinier et al., published in this issue on pages xxx. Never let a ‘good’ crisis go to waste! (attributed by some to Winston Churchill on planning to set up the United Nations during World War II) In this issue of the Journal, Galinier et al. 1 report a randomised trial of care supported by home telemonitoring including almost 1000 patients with heart failure. Telemonitoring consisted of questions about symptoms and daily weights. Data were relayed to a secure server, which generated alerts, to which nurses responded, during routine working hours, by advising patients whether they should contact their family practitioner or cardiologist. Compliance with measuring weight was often poor. We are not told how many patients contacted a doctor, what advice they received, or whether they complied with it. This complex chain of communication is only as strong as its weakest link. The trial was neutral for its composite primary endpoint, unplanned hospitalisation for heart failure or all‐cause mortality (rate ratio 0.97; P = 0.80), and for all pre‐specified secondary endpoints. A further analysis, focussing on first unplanned hospitalisation for heart failure, suggested a modest improvement (hazard ratio 0.79; P = 0.044), that was driven by larger effects in those who weighed themselves regularly or had greater functional limitation or who were more socially isolated. Some will view this trial as further evidence that home telemonitoring is ineffective for heart failure, ignoring the overall positive effect identified by systematic reviews. 2 , 3 , 4 Others will suggest the trial was neutral because of inadequate technology, lack of a robust and timely response to alerts, insufficient patient motivation and the problems inherent in conducting trials of service re‐design. Ultimately, a system that is cost‐efficient, user‐friendly and person‐centred does not need to show that it improves outcome; it only needs to show that it is not inferior to traditional ways of delivering care. 5 Now, more than ever, this evidence is reassuring. The COVID‐19 pandemic is now revolutionising attitudes to remote patient follow‐up; widespread scepticism has switched to near‐universal enthusiasm and rapid adoption into routine care. 6 The drive comes from both health professionals and patients, who want to comply with social distancing whilst ensuring continued delivery of good healthcare. This applies especially to patients with heart failure. In retrospect, it is a great shame that home telemonitoring was not already routine before the pandemic struck. This would have saved billions of healthcare ‘dollars’ worldwide as well as the stress of rapidly implementing telehealth without established infrastructure or protocols. Preparing for, rather than reacting to, a crisis seems wise, but is it rational to configure healthcare for non‐communicable diseases in future decades around the risk of pandemic infections? Perhaps not, unless there are other advantages to telecare. All those involved in telemonitoring must be motivated to support the service, most importantly the patient. Patient attitudes have changed hugely with the advent of the COVID‐19 pandemic; many are refusing to come to a healthcare facility, in primary or secondary care, even if they are unwell. Many are now eager to have healthcare delivered at home. Although some may not cope with the technology, most will have a family member or carer who can. Ultimately, home telemonitoring will not work for every patient but if it works for some, then resources can be targeted more effectively for all. The technology must be easy to install, intuitive to users and provide robust communication. Achieving uniformity across telehealth platforms for healthcare providers and medical specialities would be a bonus for patients; using a different system to manage each of a patient's medical problems is confusing, costly and impractical. Smartphones are widely available in high‐, middle‐ and most low‐income countries and solve many of these problems. Multi‐user systems in care homes or community tele‐kiosks can make even more efficient use of equipment when social distancing is not possible or not required. Voice interactive systems annoy many people and should be avoided until they can deal with local dialects. Devices should connect to systems wirelessly. Systems should provide a flexible set of modules that can be aligned to the patient's medical needs, commonly including hypertension, diabetes, coronary artery disease, atrial fibrillation, lung disease, renal dysfunction, heart failure, and mental health. Perhaps everyone with a chronic disease or everyone of retirement age should be offered telemonitoring. Ultimately, telehealth could become another standard household utility, just like electricity, gas, or the internet, providing education and trusted advice for people of all ages. Where healthcare is provided by the State or an insurance company, provision of the internet and telehealth should attract no additional cost to the patient. Better to have immediate triage by telehealth to the need for and most appropriate healthcare provider, whether that is a pharmacist, physiotherapist, family practitioner or specialist, rather than waiting days for an appointment before sitting in a waiting room for hours for a 5‐min consultation with a doctor, only to be referred on to someone else. What would you prefer? Most routine healthcare can be automated. For problems such hypertension and atrial fibrillation, patients can do non‐invasive checks, which can be fed into their electronic health record, where guideline‐driven algorithms can advise the patient and local pharmacy about which tests and treatments are required. For patients who already have a device implant, such as a loop recorder, pacemaker, defibrillator or pulmonary artery pressure monitor, even more information can be obtained. A doctor needs only enter the healthcare loop when required. Doctors and nurses should facilitate such automation rather than be sceptical and a barrier to efficient care. Physical contact may be more important for the psychology of health professionals than for patients, who may just want good care from someone they trust and can access without needing to wait weeks or months for an appointment. Clearly, some people will prefer more traditional forms of care and, for the complex cases that algorithms cannot currently manage, consultations may take longer. Rapid adoption of telehealth during the pandemic has created an opportunity to re‐design how care is delivered and by whom (mainly patients) that should be grasped. Many trials of telemonitoring for heart failure have attempted to predict and manage episodes of decompensation; this ‘crisis management’ strategy has produced inconclusive results. 7 The high rate of false‐positive alerts is its Achilles' heel. Rather than trying to detect something going wrong and fixing it, a ‘health maintenance’ strategy declares an ideal target for an individual and adjusts treatment to maintain them as close to ideal as possible. This strategy avoids the problem of false alerts and involves the patient more closely in their care. Better control of congestion will have favourable effects of atrial and ventricular remodelling, arrhythmias and pulmonary hypertension, which should improve prognosis. 8 , 9 , 10 A health maintenance strategy can be personalised and delivered by a friendly, local healthcare team. Data from hundreds of patients can be managed by automated systems, requiring staff input for only a few hours per week and can readily be integrated with physical visits in the community or hospital. Remote monitoring does not have to mean remote care. A crisis management strategy requires a 24 h, 7‐day per week service. This might be manageable at a regional or national level but too expensive for local services, unless delivered as an extension of existing facilities such as coronary care units. The two approaches are not mutually exclusive, but the former is likely to be the more feasible and cost‐effective component. 11 Patients often get bored with telemonitoring systems that provide no feedback and do not seem to ‘do’ anything. A health maintenance strategy provides much greater patient engagement and motivation through both education and patient action. 12 , 13 Educating patients, empathetically, about what treatment targets should be achieved, whether that is weight, heart rate or blood pressure, empowers them to participate in the development and delivery of care. Patients who are unaware of their care plan may struggle to help doctors deliver it. Telemonitoring can deliver health education in many formats; infographics, videos, gaming, quizzes, and inform patients of what tests they need and why and when. Measurements can also be used to determine daily doses of diuretics and some other medications. 14 The habit of giving the same diuretic dose every day arises from the lack of resources and technology to monitor requirements. Telemonitoring should be time efficient. Dentists recommend that people should spend at least 2 min twice a day brushing their teeth. A cardiovascular health check takes less time. Daily checks are probably not required for stable patients; text reminders can be scheduled less often. The focus should be on acquiring therapeutically actionable data, such as symptoms, heart rate and rhythm, weight, or more sophisticated measurements of congestion if available (Table 1 ). Pulse oximetry might be useful for managing respiratory disease including COVID‐19 infections of intermediate severity. Haematocrit, serum potassium and creatinine are actionable but no reliable, affordable method of home measurement currently exists, but technology is being developed. Local phlebotomy services, with home visits if necessary, would be a simple and inexpensive alternative. Video‐consultation can often replace clinic visits. Indeed, armed with a wealth of patient‐recorded information, linked to electronic healthcare records and supported by machine‐learning algorithms, the consultation, for both patient and health professional, may be more rewarding than a physical visit. However, video‐consultation is time‐consuming and probably not the most effective or efficient way that telemonitoring can support patient self‐management. Table 1 Actionable measurements and interventions required for care of patients with heart failure ACEi, angiotensin‐converting enzyme inhibitor; AF, atrial fibrillation; ARB, angiotensin receptor blocker; ARNI, angiotensin receptor–neprilysin inhibitor; BNP, B‐type natriuretic peptide; BP, blood pressure; CRT, cardiac resynchronisation therapy; Echo, echocardiography; GFR, glomerular filtration rate; HR, heart rate; ICD, implantable cardioverter‐defibrillator; K+, serum potassium; MRA, mineralocorticoid receptor antagonist; OAC, oral anti‐coagulant; QRS, QRS width on the electrocardiogram; Revascularisation, coronary revascularisation; SGLT2i, sodium–glucose co‐transporter 2 inhibitor; SOB, shortness of breath; Valve, valve procedure– mitral or aortic. ✓= required for monitoring during follow‐up; I = mainly for deciding on initiation or investigation; R? = consider reducing or temporarily stopping. Black = currently widely available technologies (e.g.: ECG/sphygmomanometer). Blue = technology with limited availability for use at home (e.g. bio‐impedance, blood tests). Echo is in purple, because although home monitoring is unlikely in the near future, it plays an essential role in identifying reduced left ventricular ejection fraction and valve disease and therefore in treatment selection. #BNP is a useful marker of poorly controlled congestion/heart failure and the need for further investigation/treatment. *Water retention leading to oedema (an increase in water in the tissues). Detection and treatment of subclinical oedema can prevent symptoms and improve prognosis. There are other important consequences of switching from a traditional model of care. Home telemonitoring enables patients to be part of the workforce, delivering truly individualised healthcare. 15 Even in countries with ostensibly free healthcare, the costs of getting to clinics are usually borne by the patient. Travel to and waiting at a clinic can easily take up most of a patient's day. Other hidden costs include air pollution and traffic congestion and the costs of building clinic space and carparks. Also, telemonitoring requires an associated electronic health record that enables machine learning that can generate advice for both patients and health professionals. Clearly, some people will feel uncomfortable about their data being used like this, but their concerns should not deny benefit to others. Informed patients should choose who has access to their data and for what purpose. This could benefit billions of people worldwide. Regulations that pay more attention to the worried‐well than to patients who are in need must be avoided. The pandemic has shown us the public's view on this issue. In summary, adoption of home telemonitoring as a routine clinical service for most medical problems will improve the efficiency and quality of care, reduce demands on patients, and reduce healthcare costs and environmental pollution. It will also reduce the spread of infections, whether that is the misery of seasonal rhinovirus, annual influenza, or a lethal pandemic. Let's do it—now! Funding SCI is supported by a Future Leader Fellowship, Heart Foundation of Australia. Conflict of interest: J.G.F.C. has received honoraria from Abbott, Medtronic and Philips for advisory boards. All other authors report no conflicts of interest.

          Related collections

          Most cited references14

          • Record: found
          • Abstract: found
          • Article: not found

          Clinical practice update on heart failure 2019: pharmacotherapy, procedures, devices and patient management. An expert consensus meeting report of The Heart Failure Association of the European Society of Cardiology

          The European Society of Cardiology (ESC) has published a series of guidelines on heart failure (HF) over the last 25 years, most recently in 2016. Given the amount of new information that has become available since then, the Heart Failure Association (HFA) of the ESC recognized the need to review and summarise recent developments in a consensus document. Here we report from the HFA workshop that was held in January 2019 in Frankfurt, Germany. This expert consensus report is neither a guideline update nor a position statement, but rather a summary and consensus view in the form of consensus recommendations. The report describes how these guidance statements are supported by evidence, it makes some practical comments, and it highlights new research areas and how progress might change the clinical management of HF. We have avoided re-interpretation of information already considered in the 2016 ESC/HFA guidelines. Specific new recommendations have been made based on the evidence from major trials published since 2016, including sodium-glucose co-transporter 2 inhibitors in type 2 diabetes mellitus, MitraClip for functional mitral regurgitation, atrial fibrillation ablation in HF, tafamidis in cardiac transthyretin amyloidosis, rivaroxaban in HF, implantable cardioverter-defibrillators in non-ischaemic HF, and telemedicine for HF. In addition, new trial evidence from smaller trials and updated meta-analyses have given us the chance to provide refined recommendations in selected other areas. Further, new trial evidence is due in many of these areas and others over the next 2 years, in time for the planned 2021 ESC guidelines on the diagnosis and treatment of acute and chronic heart failure.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Virtual Visits for Care of Patients with Heart Failure in the Era of COVID-19: A Statement from the Heart Failure Society of America

            Introduction Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The COVID-19 pandemic presents an unprecedented crisis for patients, clinicians, and healthcare systems in the United States (US). In response, US Federal and State governments have implemented wide-ranging stay-at-home recommendations as a means to reduce spread, and have ordered non-essential businesses to temporarily close. At the time of this writing, social distancing is the only known way to mitigate the continued spread of COVID-19, as there is currently no proven vaccine or treatment. In an effort to reduce patient exposure and transmission of disease, to conserve supplies, and to maximize personnel that are needed to provide care to the large number of severe COVID-19 cases requiring hospitalization, many US healthcare systems have reduced ambulatory outpatient clinics—pillars of the longitudinal care of patients with chronic illnesses such as heart failure (HF). In this context, synchronous audio/video interactions, also known as virtual visits (VVs), have been suggested as innovative and necessary alternatives to in-person care. VVs provide a platform for real-time interactive telehealth interactions between patients and clinicians using commonly-available home-consumer devices. Early adopters of VVs have described their feasibility, potential to save time and cost, and patient satisfaction related to increased access to care and the convenience of avoiding a trip to the office.1-5 The US Department of Veteran's Affairs (VA) has been a leader in the use of telehealth. In FY 2019, more than 99,000 Veterans used the VA Video Connect app at their home resulting in 294,000 virtual appointments.6 Although the majority of these visits were for mental health, the VA experience demonstrates the feasibility of broadly utilizing VVs to provide care for chronic illness. The value of VVs was recently demonstrated in a randomized clinical trial evaluating VVs versus in-person ambulatory visits in the post-discharge care of patients with HF (Virtual Visits in Heart Failure Care Transitions (VIV-HF); NCT03675828; Late Breaking Clinical Trial presentation at the Heart Failure of Society of America's Annual Scientific Meeting 2019 in Philadelphia, PA). The aims of this pilot study were to test the feasibility and safety of substituting in-person visits with VVs for patients (n=108) transitioning from hospital-to-home after hospitalization for HF, and to assess to what degree VVs can reduce appointment no-show rates. The no-show rate in the VV arm trended lower than observed rate in the in-person arm (VV 34.6% versus IPV 50%; RR 0.69; 95% CI 0.44 to 1.09; P=0.12), without any signal of harm—no significant differences in hospital readmission, emergency room visit, or death between the study arms.7 Yet, despite its promise, wide utilization of VVs in the US healthcare environment prior to the COVID-19 pandemic has been limited due to lack of familiarity with technologies among both clinicians and patients, concerns about the safety of substituting in-person visits with VVs, lack of integration into clinicians’ established workflows, perceived and actual legal barriers, and limited payer reimbursement.8 In the setting of the COVID-19 pandemic, many of these barriers have now disappeared given the importance of social distancing. The purpose of this statement is to provide a pragmatic guide to HF clinicians about provision of VVs in the era of the COVID-19 pandemic. First, we will outline benefits and value of VVs, some of the clinical challenges, and the recent COVID-19-related changes in policy and reimbursement that have facilitated the uptake of VVs. Then, we will outline some of the VV platforms that currently exist and describe models of care using VVs. Finally, we will describe the short-term and long-term future implications of VVs. Benefits and value of virtual visits During the current public health emergency, VVs have multiple potential benefits (Table 1 ). From a patient standpoint, VVs provide access to care where it has been significantly curtailed or entirely disappeared. By providing a platform for patients to continue to receive medical advice and instruction regarding their medical conditions, VVs have become integral to optimizing health for patients and reducing related distress while reducing in-person exposure. Given current restrictions on accompaniment during visits to medical facilities, VVs have additionally facilitated involvement by patient caregivers, who are often so critical in many of the self-care practices necessary for adults with HF.9 Some patients may find it easier to discuss difficult topics while in the comfort of their homes, and with family members who may not otherwise be present for in-person visits. From a clinician standpoint, VVs permit clinicians to continue to serve their patients from the safety of their own homes, through provision of care to their medically complex patients. The ability for a face-to-face encounter may be especially valuable in preserving patient-physician trust in the absence of in-person visits. From a healthcare systems standpoint, provision of services remotely has allowed re-allocation of resources to focus on inpatient services, which are at risk of becoming overwhelmed and saturated given the rapidity and volume of severe COVID-19 cases requiring acute inpatient care. Additionally, VVs allow continued delivery of services with reimbursement that can contribute to ensuring the financial sustainability of hospitals, practices, and the US healthcare system as a whole. Finally, VVs can be leveraged towards ensuring continuation of research studies, where patient contact is necessary for data collection, as well as ensuring safety of human subjects. Table 1 Benefits and value of virtual visits. Table 1 Group Potential benefits Patient • Provide access • Receive medical advice • Reduce in-person exposure to SARS-CoV-2 • Reduce distress • Involve caregivers Clinician • Serve patients • Reduce in-person exposure to SARS-CoV-2 • Maintain connection between patient and provider Healthcare systems • Re-allocate resources • Generate revenue • Support research efforts Challenges to virtual care To successfully conduct a VV, patients must be willing and able, and the technology must be available and effective. Accordingly, VVs may present some challenges in selected circumstances. Some patients may be reluctant to participate in VVs because they feel uncomfortable with technology, or feel self-conscious about interacting on video. These feelings may become less common as VVs enter the mainstream. VVs present a barrier to performing a full physical exam, though many components of a partial exam can be completed, and existing and emerging diagnostic technologies and wearables may fill in the gaps. This is discussed further below. Some clinicians and patients may feel that even with the use of video, VVs are not the same as in-person visits with respect to patient-physician interactions—something is lost without close proximity and the “laying on of hand.” Some patients may have limited access to the internet, and/or may not have a computer or smart device to engage in VVs, including the poor or elderly in inner city or rural areas. Although there may be geographic and financial challenges to obtaining WiFi for some patients, we anticipate that future technology will provide "hotspots" via ubiquitous cellular networks alleviating most barriers to internet access. Some health care systems are investing in these technologies and providing equipment and connectivity to ensure that telehealth does not widen health disparities.10, 11 Older adults may be viewed as a subpopulation where these challenges are common. This is particularly important because over half of patients currently living with HF in the US is older than 70 years.12 However, recent data show that an increasing number of older adults possess smartphones, and that some guidance to using newer technology can be taught, possibly by hospital/clinic support teams.13 Integration of the VVs technology platform within an institution's electronic portal or app, which is already familiar to patients, may be another approach to overcoming these challenges. Patients and clinicians may occasionally encounter technical difficulties when conducting VVs. These may include an inability to initiate the VV, connectivity issues, and/or audio/video problems. Some of this may be a direct result of larger than anticipated volume of users concurrently attempting to use a platform in the setting of the COVID-19 crisis. Over time, the hope is that software upgrades will address these issues, and that platforms will be able to accommodate a greater number and capacity of users. Of note, if/when these technical issues arise, switching to a telephone visit is a reasonable solution and remains reimbursable. Policy changes that increase feasibility of virtual visits in the era of COVID-19 Several governing bodies, including the US Executive Branch, US Congress, US Department of Health and Human Services (HHS), and State governments, have relaxed rules and regulations that have subsequently increased the feasibility of VVs. In response to the ongoing COVID-19 public health emergency the “Coronavirus Preparedness and Response Supplemental Appropriations Act, 2020”, was passed with near unanimous support by the US Congress and was signed into law by the President on March 6, 2020.14 This bill allowed HHS to “temporarily waive certain Medicare restrictions and requirements regarding telehealth services during the coronavirus public health emergency.” Then on March 13, 2020, the President proclaimed the COVID-19 outbreak a US national emergency, which allowed HHS to exercise its authority under section 1135 of the Social Security Act to temporarily waive certain requirements of Medicare, Medicaid, and the Health Insurance Portability and Accountability Act of 1996 (HIPAA).15 Specific steps taken by HHS and States are described below, and a summary of key policy changes are shown in Table 2 . Table 2 Telehealth-related policy changes in the era of COVID-19. Table 2 Topic Key policy changes: COVID-19 pandemic Implications for virtual visits Licensing HHS waived requirement for health care professionals to hold license in State which they provide services if they have an equivalent license from another state. HHS asked States to waive local licensing requirements, with final decision made at State level. Potentially allows to practice medicine via virtual visits across State lines. Privacy HHS suspended HIPAA rules. Allows use of virtual visit platforms previously deemed not HIPAA compliant. Location of patient CMS waived rural and site limitations for telehealth interactions. Allows clinicians to be reimbursed for telehealth services regardless of patient's location. Prior existing relationship CMS waived requirement that telehealth services can only be provided to a clinician's established patients. Clinicians can see new patients by telehealth. Prescription DEA relaxed rules related to prescription of controlled-substances by telehealth. Clinicians can prescribe controlled-substances in setting of a virtual visit. CMS, Centers for Medicare & Medicaid Services; DEA, Drug Enforcement Administration; HHS, US Department of Health & Human Services; HIPPA, Health Insurance Portability and Accountability Act HHS has eased a variety of rules that relate to medical licensing and privacy, which directly affect telehealth practice. First, the requirements that both physicians and other health care professionals hold licenses in the State in which they provide services were waived by the Federal government.16 Second, HIPAA privacy rules were suspended. Specifically, HHS indicated that it will “exercise its enforcement discretion and will not impose penalties for noncompliance” with HIPAA rules as they relate both to telehealth technologies, and the manner in which they are used.17 This is important because clinicians are now allowed to deliver medical care via any non-public facing VV platform, even if not previously deemed HIPAA compliant. In the short-term, this increased flexibility may lead to increased uptake of VVs. In the long-term, we recommend that HF clinicians use HIPAA compliant platforms whenever possible, both for extra security and to develop practices and habits that will be relevant in post-pandemic settings. States have individually taken a variety of steps to remove barriers to VVs in the setting of the COVID-19 pandemic. These relate to Medicaid reimbursement, licensing, and home eligibility site. The Center for Connected Health Policy is maintaining a comprehensive State-specific summary of these, which can be found on its website (https://www.cchpca.org/resources/covid-19-related-state-actions). Recent changes in reimbursement for virtual visits Reimbursement for VVs was limited prior to the COVID-19 public health emergency. With just a few exceptions, CMS reimbursed for telehealth visits only in specific circumstances: patients had to have an established relationship with their physician, had to live in a rural area, and had to be located in a medical facility at the time of the VV (“originating site”). Many commercial insurance providers reimbursed urgent care VVs (i.e., substitution of in-person emergency room or urgent care visits), with only a small number reimbursing for primary care or specialty care VVs. Meanwhile, some hospitals have started offering VVs in selected settings for certain high-risk conditions (including HF), spending institutional resources in hopes that long-term savings through bundled payment models would ultimately compensate for the associated costs of VVs, while others have offered VVs in exchange for direct cash payment from patients. In March 2020, following announcement of the COVID-19 public health emergency and the 1135 Waiver, several important telehealth-related reimbursement changes occurred. CMS announced that VVs, referred to as “telehealth visits” in CMS documents, would be reimbursed at the same rate as in-person visits during the COVID-19 crisis, without limits on the purpose of the visits, the geographical location of patients, and whether or not there was a previously established relationship with the provider. Multiple commercial insurance providers including Aetna, Cigna, Humana, and Blue Cross Blue Shield among others have followed suit. Waivers of beneficiary co-pays for these telehealth services vary among these providers. To secure reimbursement at the current time, documentation for VVs should approximate documentation for in-person ambulatory clinic visits. We recommend that clinicians explicitly document that a virtual (audio/video) visit was completed, with the patient's consent. Clinicians should document the amount of time it took to conduct the visit in minutes. Specific CPT billing codes and relevant modifiers are shown in Table 3 . The future state of EHR documentation for VVs may include capture of images or streaming clips of video interactions, automated transcription of key components of the conversation, and use of natural language processing to determine meaning and summarize information. Table 3 Billing codes for virtual visits (also called “Telehealth visits” by the Centers for Medicare & Medicaid Services). Table 3 Description Code and Modifier Office or other outpatient visit for the evaluation and management of a new patient CPT Code 99201-99205* Place of service 02 for Telehealth (Medicare), or, Modifier GT (Medicare/Medicaid) Modifier 95 (Commercial payers) Office or other outpatient visit for the evaluation and management of an established patient CPT Code 99211-99215* Place of service 02 for Telehealth (Medicare), or, Modifier GT (Medicare/Medicaid) Modifier 95 (Commercial payers) Telehealth consultations, emergency department or initial inpatient G0425 – G0427 Follow-up inpatient telehealth consultations furnished to beneficiaries in hospitals or skilled nursing facilities G0406 – G0408 *Choice of CPT code depends on whether the provider elects to use time-based coding versus component-based coding. For example, a provider using time-based coding for a Medicare beneficiary seen by VV for 15 minutes would document the time spent in their note, and then may choose CPT code 99213 with modifier GT, if otherwise appropriate to that encounter. Virtual visit platforms According to HHS, “a covered health care provider that wants to use audio or video communication technology to provide telehealth to patients during the COVID-19 nationwide public health emergency can use any non-public facing remote communication product that is available to communicate with patients.” Non-public facing products are typically platforms that employ end-to-end encryption, and which allows only an individual and the person with whom the individual is communicating to see what is transmitted. On the other hand, public facing platforms (i.e., Facebook Live, Twitch, and TikTok) are designed to be open to the public or allow wide or indiscriminate access to the communication. Table 4 outlines and describes some common platforms that may be used for VVs. Table 4 Virtual visit platforms utilized during COVID-19 public health emergency. Table 4 Name Notes Consumer apps Apple FaceTime • Popular applications that allow video chats Facebook Messenger video chat • Allowed during COVID-19 crisis, but less secure Google Hangouts video Zoom • Providers are encouraged to notify patients that these third-party applications may introduce privacy risks Skype • Providers should enable all available encryption and privacy modes when using • Use may expose provider's personal information (email account, telephone number, etc.) Specialized technology platforms Skype for Business / Microsoft Teams • Partial list of HIPAA compliant technology platforms Updox • Under normal conditions HIPAA business associate agreements for provision of telehealth services are required, but this was waved as part of COVID-19 crisis VSee Zoom for Healthcare Doxy.me Google G Suite Hangouts Meet Cisco Webex Meetings / Webex Teams Amazon Chime • Variability in cost and functionality GoToMeeting Spruce Health Care Messenger American Well MDLive BlueJeans for Healthcare Doximity HIPAA, Health Insurance Portability and Accountability Act Virtual visit models of care Which patients should be seen by virtual visits? VVs can be used to evaluate the full range of patients with HF, including those with HFpEF and HFrEF, across all Stages of HF (A-D), and including those with left ventricular assist devices (LVADs) and heart transplant recipients. Clinical assessment provided over VVs can include evaluation of clinical status, medication review and management, screening for adverse events, up-titration of guideline-directed therapy, and counseling about topics related to medication adherence, diet, and exercise. In general, outpatient visits may be classified as urgent or routine. The urgent classification includes visits for new or worsening HF symptoms, or are applicable to patients with recent LVAD implantation or heart transplantation. Using VVs to manage and triage complaints of dyspnea may be especially important during the COVID-19 crisis, given the importance of differentiating worsening HF from acute COVID-19 that could very rapidly deteriorate to respiratory failure. Individuals who are nearing Stage D HF and/or those requiring inotropes may also be important priorities due to their potential to decompensate. Routine visits could include those focused on medication titration, new test results, or time-interval associated visits. Many HF programs across the country have already converted in-person visits into VVs, keeping patients in the same previously scheduled date and time slots. Both urgent and routine visits may be conducted via VVs, depending on resource availability. An algorithm that clearly differentiates urgent from routine visits may be helpful for allocating resources. Administrative personnel and/or nurses should be trained to triage effectively according to each practice's preferences. Clinicians may also use VVs to screen urgent complaints, and decide which patients need to be seen in-person. Importantly, a variety of HF clinicians including physicians, advanced practice providers, and licensed social workers, can perform and be reimbursed for VVs.18 Pharmacists can provide VVs as well, but billing would have to occur through their supervising physician.19 Clinicians who require quarantine, but are well enough to practice, may provide an additional workforce to conduct VVs while their in-person contributions are limited. Although it is preferred that VVs occur between the patient and their usual HF clinician and team, it may be necessary in some cases for clinicians to conduct VVs with colleagues’ patients; this will likely vary across healthcare systems. What is the clinical workflow of a clinic/office practice performing telehealth virtual visits? VVs can be engineered to approximate traditional in-person visits (Table 5 ). During these visits, various personnel can obtain a history, conduct a medication reconciliation, review allergies, perform a review of systems, and subsequently document patient-reported vital signs. Leveraging VVs toward medication review by video (Figure 1 ) is particularly appealing given the number of medications that patients with HF take and the associated risk for medication errors and adverse drug events.20 To do this, clinicians can ask patients to hold pill bottles up to the camera for the clinician to visualize and review. VVs might actually be superior to a usual in-person clinic visit in this regard, since pill bottles are infrequently brought to in-person appointments. Table 5 Preparations for a successful virtual visit. Table 5 Before the VV • Determine which platform and technology will be used for the VV, and ensure that your patient can engage. • Ensure that the patient has consented for VV (verbal or written). • Position yourself centered in front of your webcam, smartphone or tablet. Adjust lighting in the room. • Confirm that video and audio are functioning appropriately. • Consider having your EHR open for live review during the VV, either on another screen or using split screen configuration. • Follow VV etiquette: conduct visit in a private professional appearing space, make sure there is no background noise or distractions, mute your audio connection when not speaking. • Collaborate with support staff who may contact patients in advance to obtain vital signs, perform medication review, and confirm time the clinician will call. This will vary by practice. During the VV • Confirm that patient's audio and video connection is established. • Maintain visual eye contact. • Ensure patient's readiness to begin. If distractions are noted, ask to minimize them. • Determine if this is their first experience with VV and acknowledge uneasiness if any. Let the patient know they can interrupt at any time, if they have issues with the platform, or the visit in any way • Guide the patient through maneuvering the camera for a physical examination. • Address need for laboratory studies. • Use teach-back and ask the patient to write down important instructions, medication changes, and their follow up plan. Reinforce usual self-care. • End the visit with asking the patient how the experience was for them, what worked well, what could be better and use this for planning future visits. After the VV • Document in the EHR: VV performed with a VV attestation and time spent, nature of the visit and who was present. Consider a specific designation for the note (e.g., Heart Failure Virtual Visit). • Email, mail, or message patient any medication updates or specific instructions for care. • Arrange for laboratory testing, if needed. • Bill for the encounter. • Plan for the next visit. Figure 1 Screen shots from video virtual visits between a HF cardiologist (right lower hand corner) and a patient. (A.) Medication review by video. (B.) Examination of ankles showing sock markings without edema, and (C.) neck examination. Figure 1 Basic components of the physical exam can be performed via telehealth, especially when patients use high-quality video equipment available on contemporary smartphones and tablets (Figure 1). These components may include general appearance, including alertness and orientation, as well as an assessment of volume status by looking for signs of peripheral edema such as leg swelling, and/or remote evaluation of neck veins. Assessment of neck veins is best done with a second person moving the camera position relative to the patient's neck in order to obtain the appropriate angle and lighting. Recent data have demonstrated that assessment of neck veins with video magnification technology correlates with invasively measured right atrial pressure.21 Assessment of orthopnea and bendopnea may also be done remotely, both of which are associated with elevated ventricular filling pressures.22, 23 VVs may also permit an assessment of exercise intolerance, for example by asking the patient to walk from room to room or up a flight of stairs. Finally, it is possible to use VVs to examine peripherally inserted central catheter line sites and other cannulae, as well as healing surgical incisions such as pacemaker or ICD implantation sites. Adjuncts to virtual visits Several remote monitoring capabilities are already in use for the care of patients with HF and can complement data collected during VVs.24 The most basic is remote monitoring of weight and blood pressure via electronic scales and blood pressure cuffs. CardioMEMS, a hemodynamic monitor implanted into the pulmonary artery that remotely transmits pulmonary artery pressures, has been shown to reduce hospital readmissions and improve quality of life, and thus may be used in addition to telehealth visits to guide therapy.25, 26 Similarly, remote ICD interrogation to assess arrhythmia burden can provide additional information. Whether wearable devices for ambulatory cardiac monitoring such as wristwatches, smartphones, patches, headbands, eye-glasses, necklaces, or vests can be integrated into clinical management provided through VVs is unknown, and warrants future investigation.27-29 Advance care planning VVs provide a unique opportunity to engage patients and caregivers on topics related to advance care planning, which are of heightened importance during the COVID-19 pandemic, especially among higher risk populations. Conducting these conversations while the patient (and their caregivers) are in the comfort of their own homes may provide the optimal setting for these discussions. As the COVID-19 crisis unfolds, issues related to becoming acutely ill may very well be on the minds of many patients with HF. Accordingly, it may be appropriate to discuss care preferences during VVs. Questions that may be routinely incorporated into the discussion include: • “Have you appointed a health care proxy?—this is a person who would make decisions on your behalf if you were unable to make decisions.” • “Have you completed an advance directive form?” • “Does your health care proxy and/or family know what your care preferences would be if you were to get sick and could not make decisions for yourself?” • “Do you have a healthcare power of attorney form?—this is a legal document that gives one person the authority to make health care decisions for you if you are unable to do so.” Pharmacy considerations following a virtual visit One of the major goals of VVs is to reduce exposure to others who could be potentially infected by the SARS-CoV-2 virus. Consistent with this goal, it is equally important to consider patient strategies for obtaining medications that permit social distancing. Delivery of medications to the patient's home is one method to reduce exposure. Approximately 20% of patients historically use mail delivery pharmacy services, which means the majority of the population will need to navigate this process for the first time during the current public health crisis.30 National mail-delivery pharmacies may be a long-term solution for many patients, but new patients and/or prescriptions will typically experience a 1-2 week delay before delivery. It may thus be prudent to use independent and chain pharmacies, many of which can deliver medications within their communities on the same or next day. Of note, various pharmacy chains have waived delivery fees during the COVID-19 crisis. For patients unwilling or unable to use these services, selecting a pharmacy location with a drive-up window may provide an alternative solution that permits some degree of social distancing. Clinicians should consider prescribing a 90-day supply when appropriate and helping patients synchronize all medication refills to a common schedule to reduce the number of trips to a pharmacy; especially now that many of the traditional legal and administrative barriers to these efforts have been removed for COVID-19. Both CMS Part D sponsors and commercial pharmacy benefit managers have relaxed restrictions on early refills and now allow the maximum day supply (most commonly 90 days) for medications to be filled. Additionally, many States have instituted emergency actions to facilitate medication access such as allowing pharmacies to dispense an emergency 30-day supply of chronic, non-controlled medications when patients are awaiting refill authorization from providers. A continually updated list of pharmacy-related state actions impacting medication access sorted by State is available at the National Alliance of State Pharmacy Associations website (https://naspa.us/resource/covid-19-information-from-the-states). Inpatient use of telehealth While this statement is primarily focused on leveraging VVs for continued ambulatory care of adults with HF, these principles also apply to the inpatient setting. Given concerns about shortages in personal protective equipment, VVs may be beneficial to clinicians working in the inpatient setting, and have already been implemented by some healthcare systems across the US. Approaches vary but most commonly involve the use of either hospital-provided or the patient's own smartphone or tablet. Software platforms reportedly being used include Apple FaceTime, Cisco Jabber, and Microsoft Team among others, some of which allow multiple team members to connect and conduct virtual rounds together. These visits may be enriched by the use of Bluetooth stethoscopes and/or point-of-care ultrasound technology that can provide valuable information about the physical exam while limiting exposure. Of note, VVs for inpatient care are reimbursable (Table 3) and equivalent to in-person hospital service. If the consultant is outside of the hospital and the patient is in the hospital, these inpatient encounters can be billed as an ambulatory telehealth visit. Future of virtual visits after resolution of the COVID-19 pandemic COVID-19 has saturated some hospitals with high volumes of patients with respiratory syndromes and respiratory failure, and subsequently forced the medical community to rely on VVs to provide routine care to many patients with chronic medical illnesses like HF. Importantly, survivors will likely require prolonged time for recovery, and it remains unclear where these patients will recover and rehabilitate. At the present time, many rehabilititation and long-term care facilities do not accept patients who were COVID-19 positive, due to concerns about disease transmission. It is therefore possible that some US hospitals will remain at capacity well-beyond the time period of the COVID-19 surge. Additionally, emerging data suggest that at least 20% of COVID-19 positive patients are health care providers, which will stretch the active work force even further. Thus, continuing resource-efficient strategies like VVs may be necessary for the near and intermediate future. It is unclear what the psychological impact of COVID-19 will be on providers and patients, especially among those patients who are at highest risk—which include those with chronic conditions like HF. An important consideration is that, even after the COVID-19 crisis ends, patients may continue to have concerns about in-person office visits and travel, and prefer to continue with a degree of social distancing. As a result, many patients with HF may continue to prefer VVs. Prior to the COVID-19 pandemic, there was little impetus for clinicians to learn or embrace VVs. In the current era, many clinicians have been forced to learn and use VVs. Consequently, as we move beyond the COVID-19 pandemic, clinicians may be more amenable to VVs; in fact, some may even prefer them. With these expectations in mind we believe that VV models of care will become the norm in the US healthcare system moving forward, especially for patients with HF. Many patients with HF, especially older adults with disabilities, and those living in rural communities often have difficulty attending in-person visits due to very poor exercise tolerance, inadquate transportation, and difficulty transporting oxgyen among other barriers. For these patients VVs are certainly more convenient, and likewise for their caregivers, who sometimes have to take off work to bring their family member to the appointment. Policy and reimbursement practices developed in response to the COVID-19 public health emergency and discussed in this document may remain and further evolve to accommodate continued use of VVs. We suspect that it is possible if not likely that CMS will continue incenting VVs, though likely at lower reimbursement rates than in-person visits. Distance health technologies that align with VVs, including biosensing wearables28, 31 and other diagnostic tools, may be increasingly adopted. Whether the use of VVs can improve adherence, decrease no-show rates, decrease office overhead, improve transitions of care from the inpatient to outpatient setting, or prevent ER visits and hospital admissions/readmissions for patients with HF is yet unknown. This underscores the need to collect outcomes data. While frightening to consider, we will be better able to pivot when the next pandemic comes along with VV systems in place. Regardless, the COVID-19 pandemic has generated an important opportunity to learn about delivering HF care in a different way that should be fully embraced well beyond the current crisis. Disclosures No relevant conflicts of interest. References 1. White T, Watts P, Morris M and Moss J. Virtual Postoperative Visits for New Ostomates. Comput Inform Nurs. 2019;37:73-79. 2. Tasneem S, Kim A, Bagheri A and Lebret J. Telemedicine Video Visits for patients receiving palliative care: A qualitative study. Am J Hosp Palliat Care. 2019;36:789-794. 3. Nord G, Rising KL, Band RA, Carr BG and Hollander JE. On-demand synchronous audio video telemedicine visits are cost effective. Am J Emerg Med. 2019;37:890-894. 4. Crossen S, Glaser N, Sauers-Ford H, Chen S, Tran V and Marcin J. Home-based video visits for pediatric patients with poorly controlled type 1 diabetes. J Telemed Telecare. 2019:1357633X19828173. 5. Thiyagarajan A, Grant C, Griffiths F and Atherton H. Exploring patients' and clinicians' experiences of video consultations in primary care: a systematic scoping review. BJGP Open. 2020. 6. VA reports significant increase in Veteran use of telehealth services. Office of Public and Intergovernmental Affairs, US Department of Veterans Affairs. November 22, 2019. https://www.va.gov/opa/pressrel/pressrelease.cfm?id=5365. Last accessed April 5, 2020. 7. Gorodeski EZ, Moennich LA, Riaz H and Tang WHW. Virtual Visits Versus In-Person Visits and Appointment No-Show Rates. Journal of Cardiac Failure. 2019;25:939. 8. Fraiche AM, Eapen ZJ and McClellan MB. Moving Beyond the Walls of the Clinic: Opportunities and Challenges to the Future of Telehealth in Heart Failure. JACC Heart Fail. 2017;5:297-304. 9. Riegel B, Lee CS, Dickson VV and Medscape. Self care in patients with chronic heart failure. Nat Rev Cardiol. 2011;8:644-54. 10. deShazo RD and Parker SB. Lessons Learned from Mississippi's Telehealth Approach to Health Disparities. The American journal of medicine. 2017;130:403-408. 11. Baker J and Stanley A. Telemedicine Technology: a Review of Services, Equipment, and Other Aspects. Current Allergy and Asthma Reports. 2018;18:60. 12. Gorodeski EZ, Goyal P, Hummel SL, Krishnaswami A, Goodlin SJ, Hart LL, Forman DE, Wenger NK, Kirkpatrick JN, Alexander KP and Geriatric Cardiology Section Leadership Council ACoC. Domain Management Approach to Heart Failure in the Geriatric Patient: Present and Future. J Am Coll Cardiol. 2018;71:1921-1936. 13. Anderson M., Perrin A. Tech adoption climbs among older adults. Pew Research Center. May 17, 2017. http://www.pewinternet.org/2017/05/17/tech-adoption-climbs-among-older-adults/pi_2017-05-17_older-americans-tech_1-03/. Last accessed April 9, 2020. 14. Coronavirus Preparedness and Response Supplemental Appropriations Act, H.R.6074, 116th Cong. (2019-2020). https://www.congress.gov/bill/116th-congress/house-bill/6074/text. Last accessed April 5, 2020. 15. Trump, DJ. Proclamation on Declaring a National Emergency Concerning the Novel Coronavirus Disease (COVID-19) Outbreak. The White House. March 13, 2020. https://www.whitehouse.gov/presidential-actions/proclamation-declaring-national-emergency-concerning-novel-coronavirus-disease-covid-19-outbreak. Last accessed April 5, 2020. 16. Azar, AM. Waiver or Modification of Requirements Under Section 1135 of the Social Security Act. US Department of Health & Human Services. https://www.phe.gov/emergency/news/healthactions/section1135/Pages/covid19-13March20.aspx. March 13, 2020. Last accessed April 5, 2020. 17. Notification of Enforcement Discretion for Telehealth Remote Communications During the COVID-19 Nationwide Public Health Emergency. US Deparment of Health & Human Services. March 17, 2020. https://www.hhs.gov/hipaa/for-professionals/special-topics/emergency-preparedness/notification-enforcement-discretion-telehealth/index.html. Last accessed April 5, 2020. 18. Medicare Telemedicine Health Care Provider Fact Sheet. Centers for Medicare & Medicaid Services. March 17, 2020. https://www.cms.gov/newsroom/fact-sheets/medicare-telemedicine-health-care-provider-fact-sheet. Last accessed April 5, 2020. 19. Physicians and Other Clinicians: CMS Flexibilities to Fight COVID-19. March 30, 2020. https://www.cms.gov/files/document/covid-19-physicians-and-practitioners.pdf. Last accessed April 12, 2020. 20. Goyal P, Bryan J, Kneifati-Hayek J, Sterling MR, Banerjee S, Maurer MS, Lachs MS and Safford MM. Association Between Functional Impairment and Medication Burden in Adults with Heart Failure. J Am Geriatr Soc. 2019;67:284-291. 21. Abnousi F, Kang G, Giacomini J, Yeung A, Zarafshar S, Vesom N, Ashley E, Harrington R and Yong C. A novel noninvasive method for remote heart failure monitoring: the EuleriAn video Magnification apPLications In heart Failure studY (AMPLIFY). NPJ Digit Med. 2019;2:80. 22. Thibodeau JT, Turer AT, Gualano SK, Ayers CR, Velez-Martinez M, Mishkin JD, Patel PC, Mammen PP, Markham DW, Levine BD and Drazner MH. Characterization of a novel symptom of advanced heart failure: bendopnea. JACC Heart Fail. 2014;2:24-31. 23. Drazner MH, Hellkamp AS, Leier CV, Shah MR, Miller LW, Russell SD, Young JB, Califf RM and Nohria A. Value of clinician assessment of hemodynamics in advanced heart failure: the ESCAPE trial. Circ Heart Fail. 2008;1:170-7. 24. Dickinson MG, Allen LA, Albert NA, DiSalvo T, Ewald GA, Vest AR, Whellan DJ, Zile MR and Givertz MM. Remote Monitoring of Patients With Heart Failure: A White Paper From the Heart Failure Society of America Scientific Statements Committee. J Card Fail. 2018;24:682-694. 25. Adamson PB, Abraham WT, Bourge RC, Costanzo MR, Hasan A, Yadav C, Henderson J, Cowart P and Stevenson LW. Wireless pulmonary artery pressure monitoring guides management to reduce decompensation in heart failure with preserved ejection fraction. Circ Heart Fail. 2014;7:935-44. 26. Heywood JT, Jermyn R, Shavelle D, Abraham WT, Bhimaraj A, Bhatt K, Sheikh F, Eichorn E, Lamba S, Bharmi R, Agarwal R, Kumar C and Stevenson LW. Impact of Practice-Based Management of Pulmonary Artery Pressures in 2000 Patients Implanted With the CardioMEMS Sensor. Circulation. 2017;135:1509-1517. 27. Perez MV, Mahaffey KW, Hedlin H, Rumsfeld JS, Garcia A, Ferris T, Balasubramanian V, Russo AM, Rajmane A, Cheung L, Hung G, Lee J, Kowey P, Talati N, Nag D, Gummidipundi SE, Beatty A, Hills MT, Desai S, Granger CB, Desai M, Turakhia MP and Apple Heart Study I. Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation. N Engl J Med. 2019;381:1909-1917. 28. Sana F, Isselbacher EM, Singh JP, Heist EK, Pathik B and Armoundas AA. Wearable Devices for Ambulatory Cardiac Monitoring: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020;75:1582-1592. 29. Abraham WT, Anker S, Burkhoff D, Cleland J, Gorodeski E, Jaarsma T, Small R, Lindenfeld J, Miller A and Ogenstad S. Primary Results of the Sensible Medical Innovations Lung Fluid Status Monitor Allows Reducing Readmission Rate of Heart Failure Patients (smile) Trial. Journal of Cardiac Failure. 2019;25:938. 30. Ma J and Wang L. Characteristics of Mail-Order Pharmacy Users: Results From the Medical Expenditures Panel Survey. J Pharm Pract. 2018:897190018800188. 31. DeVore AD, Wosik J and Hernandez AF. The Future of Wearables in Heart Failure Patients. JACC Heart Fail. 2019;7:922-932.
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Prevalence, pattern and clinical relevance of ultrasound indices of congestion in outpatients with heart failure

                Bookmark

                Author and article information

                Contributors
                john.cleland@glasgow.ac.uk
                Journal
                Eur J Heart Fail
                Eur. J. Heart Fail
                10.1002/(ISSN)1879-0844
                EJHF
                European Journal of Heart Failure
                John Wiley & Sons, Ltd. (Oxford, UK )
                1388-9842
                1879-0844
                01 June 2020
                : 10.1002/ejhf.1864
                Affiliations
                [ 1 ] Robertson Centre for Biostatistics & Glasgow Clinical Trials Unit, Institute of Health and Wellbeing University of Glasgow, Glasgow Royal Infirmary Glasgow UK
                [ 2 ] South Australian Health and Medical Research Institute (SAHMRI) Flinders University Adelaide Australia
                [ 3 ] Faculty of Health University of Technology Sydney Sydney Australia
                Author notes
                [*] [* ] Corresponding author. Robertson Centre for Biostatistics & Glasgow Clinical Trials Unit, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK. Tel/Fax: +44 1895 453895, Email: john.cleland@ 123456glasgow.ac.uk

                Article
                EJHF1864
                10.1002/ejhf.1864
                7273055
                32385954
                e30d1cc3-e581-44cd-9450-719819dffc30
                © 2020 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 01 May 2020
                : 02 May 2020
                Page count
                Figures: 0, Tables: 1, Pages: 4, Words: 2501
                Categories
                Editorial Comment
                Editorial Comments
                Custom metadata
                2.0
                corrected-proof
                Converter:WILEY_ML3GV2_TO_JATSPMC version:5.8.3 mode:remove_FC converted:05.06.2020

                Cardiovascular Medicine
                Cardiovascular Medicine

                Comments

                Comment on this article